o-Isobutyranisidide

Base Information

• Chemical Name: o-Isobutyranisidide
• CAS No.: 71182-38-2
• Molecular Formula: C11H15 N O2
• Molecular Weight: 193.24
• Mol file: 71182-38-2.mol

Synonyms:o-Isobutyranisidide(7CI); NSC 15677

Chemical Property of o-Isobutyranisidide

Chemical Property:

• Vapor Pressure: 0.000247mmHg at 25°C
• Boiling Point: 324.4°C at 760 mmHg
• Flash Point: 150°C
• PSA: 38.33000
• Density: 1.074g/cm³
• LogP: 2.36270

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Isobutyranisidide

There total 2 articles about o-Isobutyranisidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-phenylamine (90-04-0) + isobutyryl chloride (79-30-1) → o-Isobutyranisidid (71182-38-2)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 1h;

DOI:10.1021/jm00355a010

Reference yield:

→ o-Isobutyranisidid (71182-38-2)

Guidance literature:

Isobuttersaeureanhydrid, o-Anisidin;

Reference yield:

o-Isobutyranisidid (71182-38-2) + 1-(o-chloro phenethyl)-4-piperidone (39742-61-5) → 2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(2-methoxy-phenyl)-isobutyramide

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min;

DOI:10.1021/jm00355a010

upstream raw materials:

2-methoxy-phenylamine

isobutyryl chloride

Refernces