Synthesis and Pharmacological Studies of 4,4-Disubstituted Piperidines: A New Class of Compounds with Potent Analgesic Properties

DOI: 10.1021/jm00355a010

Source and publish data:

Journal of Medicinal Chemistry p. 42 - 50 (1983)

Update date:2022-08-04

Topics: Synthesis

Authors:

Huegi, Bruno S.

Ebnoether, Anton M.

Rissi, Erwin

Gadient, Fulvio

Hauser, Daniel

et al. et al.

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Article abstract of DOI:10.1021/jm00355a010

A series of 4,4-disubstituted piperidines has been synthesized and evaluated for analgesic activity.Several of these analogues show analgesic potency comparable to morphine in the mouse writhing and tail-flick tests.A number of compounds exhibit high affi

Full text of DOI:10.1021/jm00355a010

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