(PHENYLTHIO)PROPANONE

Base Information

• Chemical Name: (PHENYLTHIO)PROPANONE
• CAS No.: 5042-53-5
• Molecular Formula: C9H10OS
• Molecular Weight: 166.244
• Hs Code.: 2930909090
• Mol file: 5042-53-5.mol

Synonyms:2-Propanone,(phenylthio)- (6CI,7CI);(Phenylthio)-2-propanone;(Phenylthio)acetone;1-(Phenylthio)-2-propanone;1-(Phenylthio)acetone;Acetonyl phenyl sulfide;N-Benzenesulfenyl-2-propanone;NSC 60970;

Chemical Property of (PHENYLTHIO)PROPANONE

Chemical Property:

• Vapor Pressure: 0.0194mmHg at 25°C
• Melting Point: 32-34 °C
• Refractive Index: 1.561
• Boiling Point: 252.4 °C at 760 mmHg
• Flash Point: 114.7 °C
• PSA: 42.37000
• Density: 1.1 g/cm³
• LogP: 2.36770
• Storage Temp.: Keep Cold

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Phenylthio)propan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(Phenylthio)propan-2-one is a useful reagent for the preparation of (oxo-phenylsulfanyl)benzoates.

Technology Process of (PHENYLTHIO)PROPANONE

There total 57 articles about (PHENYLTHIO)PROPANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiophenol (108-98-5) + 1-bromoacetone (598-31-2) → 1-(phenylsulfanyl)acetone (5042-53-5)

Guidance literature:

With 1-pentyl-3-methylimidazolium bromide; at 25 - 30 ℃; for 0.166667h;

DOI:10.1002/adsc.200505122

Reference yield: 97.0%

thiophenol (108-98-5) + chloroacetone (78-95-5) → 1-(phenylsulfanyl)acetone (5042-53-5)

Guidance literature:

With triethylamine; In acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol3007698

Reference yield: 93.0%

sodium thiophenolate (930-69-8) + chloroacetone (78-95-5) → 1-(phenylsulfanyl)acetone (5042-53-5)

Guidance literature:

In methanol;

DOI:10.1016/S0040-4039(00)81635-4

upstream raw materials:

sodium thiophenolate

chloroacetone

phenyl propargyl sulfide

thiophenol

Downstream raw materials:

(R,S)-1-(phenylthio)-2-aminopropane hydrochloride

2-methyl-2-phenylsulfanylbutan-3-one

(Z)-3-Phenylsulfanyl-oct-3-en-2-one

(E)-3-Phenylsulfanyl-undec-5-en-2-one

Refernces

• 1、 Anselmi, Silvia,Liu, Siyu,Kim, Seong-Heun,Barry, Sarah M.,Moody, Thomas S.,Castagnolo, Daniele. "A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent". supporting information. p. 156 - 161. Retrieved 2021/01/14.
• 2、 Wang, Lingxiao,Qiao, Jie,Wei, Jiancong,Liang, Zhiwu,Xu, Xinhua,Li, Ningbo. "Air-stable binuclear Titanium(IV) salophen perfluorobutanesulfonate with zinc power catalytic system and its application to C–S and C–Se bond formation". . . Retrieved 2020/01/08.