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14963-97-4

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14963-97-4 Usage

Uses

3-Methoxyphthalic Acid has metallo-β-lactamase inhibitory activity.

Check Digit Verification of cas no

The CAS Registry Mumber 14963-97-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,6 and 3 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 14963-97:
(7*1)+(6*4)+(5*9)+(4*6)+(3*3)+(2*9)+(1*7)=134
134 % 10 = 4
So 14963-97-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H8O5/c1-14-6-4-2-3-5(8(10)11)7(6)9(12)13/h2-4H,1H3,(H,10,11)(H,12,13)

14963-97-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-methoxyphthalic acid

1.2 Other means of identification

Product number -
Other names 3-Methoxyphthalsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14963-97-4 SDS

14963-97-4Relevant articles and documents

Regioselective Reduction of Anhydrides by L-Selectride

Makhlouf, Mansour A.,Rickborn, Bruce

, p. 4810 - 4811 (1981)

-

Methylation and Hydroxylation Studies on Aloe-emodin

Alexander, Jose,Bhatia, Ashok V.,Mitscher, Lester A.,Omoto, Shoji,Suzuki, Toshio

, p. 20 - 24 (1980)

The chemistry of aloe-emodin (3) has been explored with a view toward its use as a synthon for the regiospecific synthesis of adriamycin and analogues of it.Routes for satisfactory large-scale monomethyl ether formation at C8 (4) and regiospecific introduction of a phenolic oxygen function at C4 (21) are described.Interesting side reactions were encountered, including an apparent peri O to O acyl wandering reaction during methylation and a reductive debromination reaction during displacement of an aryl bromide by methanolic methoxide.

Synthetic process of rhein

-

Paragraph 0019; 0021; 0024, (2018/03/07)

The invention relates to a synthetic process of rhein. The synthetic process comprises the steps of: adopting 2,3-dimethyl phenol as a raw material, performing methylation and oxidation to obtain 3-methoxy phthalic acid, performing dehydration by using acetic anhydride to obtain acid anhydride, then performing a Friedel-Crafts reaction between the obtained acid anhydride and excess methyl anisoleunder the action of aluminum trichloride to obtain the product, and then conducting cyclization by using sulfuric acid to obtain an intermediate chrysophanol, performing acetylation on the obtained chrysophanol, performing oxidation to obtain diacerein, and finally carrying out deacetylation to synthesize rhein.

Metallo-β-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem

Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki

, p. 5841 - 5850 (2013/09/12)

3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-β-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-β-lactamase, IMP-1 inhibitory activity and a strong combination effect with biapenem (BIPM), carbapenem antibiotic. In particular, the 4′-hydroxy-piperidine derivative showed strong IMP-1 inhibitory activity and a combination effect with various antibiotics.

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