1H-Inden-1-one, 2,3-dihydro-5-hydroxy-7-(1-methylethyl)-

Base Information

Chemical Name:1H-Inden-1-one, 2,3-dihydro-5-hydroxy-7-(1-methylethyl)-
CAS No.:676121-65-6
Molecular Formula:C12H14O2
Molecular Weight:190.242
Hs Code.:

Synonyms:

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Chemical Property of 1H-Inden-1-one, 2,3-dihydro-5-hydroxy-7-(1-methylethyl)-

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Technology Process of 1H-Inden-1-one, 2,3-dihydro-5-hydroxy-7-(1-methylethyl)-

There total 1 articles about 1H-Inden-1-one, 2,3-dihydro-5-hydroxy-7-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65651-63-0,38836-21-4
4-hydroxy-5-methyl-hexan-2-one

: 676121-65-6
5-hydroxy-7-isopropyl-1-indanone

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / p-TsOH*H₂O; Na₂SO₄ / benzene / 5 h / 90 °C

2: 79 percent / LiN(TMS)2 / tetrahydrofuran; toluene / 1.17 h / -78 - 20 °C

3: 2,5-di-tert-butylhydroquinone / benzene / 56 h / 200 °C

4: p-TsOH*H₂O / acetone / 0.5 h / 20 °C

5: 75 percent / p-cymene / Pd/C / 45 h / 200 °C

With 4-methylisopropylbenzene; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; toluene-4-sulfonic acid; sodium sulfate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; acetone; toluene; benzene; 3: Diels-Alder reaction;
DOI:10.1021/jo049381f

Reference yield: 97.0%

: 98-59-9
p-toluenesulfonyl chloride

: 676121-65-6
5-hydroxy-7-isopropyl-1-indanone

: 848760-13-4
5-p-toluenesulfonyloxy-7-isopropyl-1-indanone

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1021/jo049381f

Reference yield:

: 676121-65-6
5-hydroxy-7-isopropyl-1-indanone

: 461641-20-3
(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 97 percent / NaH / tetrahydrofuran / 2.5 h / 20 °C

2.1: 87 percent / NaBH₄; NiCl₂*6H₂O / methanol / 3 h / 0 - 20 °C

3.1: 100 percent / pTsOH*H₂O / benzene / 0.67 h / 20 - 100 °C

4.1: 86 percent / mCPBA; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; N-methylmorpholine N-oxide / CH₂Cl₂ / 1 h / -78 °C

5.1: H₂SO₄; acetonitrile / hexane / 1 h / 20 °C

5.2: 39 percent / H₂O / 2 h / 100 °C

6.1: CHCl₃ / 3 h / 24 °C

7.1: 1.12 g / LiAlH₄ / diethyl ether; tetrahydrofuran / 0.08 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; sulfuric acid; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; 3-chloro-benzenecarboperoxoic acid; acetonitrile; nickel dichloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; benzene; 4.1: Jacobsen reaction / 5.1: Ritter reaction;
DOI:10.1021/jo049381f