Des(oxopentyl) Valsartan Benzyl Ester

Base Information

• Chemical Name: Des(oxopentyl) Valsartan Benzyl Ester
• CAS No.: 676129-93-4
• Molecular Formula: C26H27N5O2
• Molecular Weight: 441.533
• Mol file: 676129-93-4.mol

Synonyms:

Chemical Property of Des(oxopentyl) Valsartan Benzyl Ester

Chemical Property:

• PSA: 92.79000
• LogP: 4.78220

Purity/Quality:

97% ^*data from raw suppliers

Des(oxopentyl)ValsartanBenzylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Des(oxopentyl) Valsartan Benzyl Ester

There total 17 articles about Des(oxopentyl) Valsartan Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate (1307853-55-9) → (S)-3-methyl-2-((2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl)-amino)-butyric acid benzyl ester (676129-93-4)

Guidance literature:

With trifluoroacetic acid; In methoxybenzene; at 60 ℃; for 2.5h; Inert atmosphere;

Reference yield:

C26H25N5O2 → (S)-3-methyl-2-((2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl)-amino)-butyric acid benzyl ester (676129-93-4)

Guidance literature:

C₂₆H₂₅N₅O₂; With sodium tetrahydroborate; In ethanol; at 0 - 5 ℃; for 0.666667h;

With hydrogenchloride; In ethanol; water; pH=6 - 7;

Reference yield:

5-Phenyl-1H-tetrazole (18039-42-4,3999-10-8) → (S)-3-methyl-2-((2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl)-amino)-butyric acid benzyl ester (676129-93-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice

1.2: 1 h

2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 85 °C

6.1: trifluoroacetic acid / methoxybenzene / 2.5 h / 60 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium methylate; phosphorus tribromide; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; chloroform; water; methoxybenzene; acetonitrile;

upstream raw materials:

benzoyl chloride

4-bromobenzyl acetate

4-bromobenzenemethanol

5-Phenyl-1H-tetrazole

Downstream raw materials:

(S)-N-(1-benzyloxycarbonyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine