benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate

Base Information

Chemical Name:benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate
CAS No.:1307853-55-9
Molecular Formula:C₃₄H₃₅N₅O₃
Molecular Weight:561.684
Hs Code.:

Synonyms:benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate

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Chemical Property of benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate

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Technology Process of benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate

There total 10 articles about benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1307853-40-2
5-[4'-(bromomethyl)biphenyl-2-yl]-1-(p-methoxybenzyl)-1H-tetrazole

: 16652-76-9
L-valine benzyl ester p-toluenesulfonate salt

: 1307853-55-9
benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1307853-55-9
benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice

1.2: 1 h

2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 85 °C

With tetrabutylammomium bromide; sodium methylate; phosphorus tribromide; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; chloroform; water; acetonitrile;

Reference yield:

: 18039-42-4,3999-10-8
5-Phenyl-1H-tetrazole

: 1307853-55-9
benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice

1.2: 1 h

2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 85 °C

With tetrabutylammomium bromide; sodium methylate; phosphorus tribromide; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; chloroform; water; acetonitrile;