1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-(2,2-dimethylpropyl)-3,4-dihydro-, phenylmethyl ester

Base Information

Chemical Name:1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-(2,2-dimethylpropyl)-3,4-dihydro-, phenylmethyl ester
CAS No.:676136-59-7
Molecular Formula:C34H41F2N3O4
Molecular Weight:593.714
Hs Code.:

1(2H)-Quinolinecarboxylic acid,
4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino
]-6-(2,2-dimethylpropyl)-3,4-dihydro-, phenylmethyl ester

Synonyms:

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Chemical Property of 1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-(2,2-dimethylpropyl)-3,4-dihydro-, phenylmethyl ester

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Technology Process of 1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-(2,2-dimethylpropyl)-3,4-dihydro-, phenylmethyl ester

There total 2 articles about 1(2H)-Quinolinecarboxylic acid, 4-[[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino ]-6-(2,2-dimethylpropyl)-3,4-dihydro-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: benzyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate

: 128459-09-6
N-acetyl-N-methoxyacetamide

: 676136-59-7
benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate

Guidance literature:: benzyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate; N-acetyl-N-methoxyacetamide; In dichloromethane; at 20 ℃; for 72h;

With hydrogenchloride; In dichloromethane; water;

Reference yield: 99.0%

: 676136-58-6
benzyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate

: 128459-09-6
N-acetyl-N-methoxyacetamide

: 676136-59-7
benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 676136-59-7
benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate

: 676136-52-0
N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-neopentyl-1,2,3,4-tetrahydroquinolin-4-yl)amino]propyl}acetamide

Guidance literature:: benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; for 4.5h; under 2430.66 Torr;

With sodium hydrogencarbonate; In water; ethyl acetate;