3,4-DIAMINOBENZOTRIFLUORIDE

Base Information

• Chemical Name: 3,4-DIAMINOBENZOTRIFLUORIDE
• CAS No.: 368-71-8
• Molecular Formula: C7H7F3N2
• Molecular Weight: 176.141
• Hs Code.: 29215900
• Mol file: 368-71-8.mol

Synonyms:Toluene-3,4-diamine,a,a,a-trifluoro- (6CI,8CI);1,2-Diamino-4-(trifluoromethyl)benzene;2-Amino-4-(trifluoromethyl)aniline;2-Amino-5-(trifluoromethyl)aniline;4-(Trifluoromethyl)-1,2-phenylenediamine;4-(Trifluoromethyl)-o-phenylenediamine;4-Trifluoromethyl-1,2-benzenediamine;4-Trifluoromethyl-1,2-diaminobenzene;

Chemical Property of 3,4-DIAMINOBENZOTRIFLUORIDE

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00539mmHg at 25°C
• Melting Point: 56-58 °C
• Refractive Index: 1.535
• Boiling Point: 252.7 °C at 760 mmHg
• PKA: 2.94±0.10(Predicted)
• Flash Point: 111.1 °C
• PSA: 52.04000
• Density: 1.381 g/cm³
• LogP: 3.03220
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility.: Miscible with water.

Purity/Quality:

97% ^*data from raw suppliers

3,4-Diaminobenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Diaminobenzotrifluoride is commonly used as pharmaceutical intermediate.

Technology Process of 3,4-DIAMINOBENZOTRIFLUORIDE

There total 6 articles about 3,4-DIAMINOBENZOTRIFLUORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-trifluoromethyl-2-nitroaniline (400-98-6) → 4-(trifluoromethyl)-1,2-phenylenediamine (368-71-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2005.08.060

Reference yield: 54.0%

4-methyl-N-{2-(pyrimidin-2-ylamino)-5-(trifluoromethyl)phenyl}benzenesulfonamide → 4-(trifluoromethyl)-1,2-phenylenediamine (368-71-8)

Guidance literature:

With hydrogenchloride; In water; at 150 ℃; for 3h; Microwave irradiation;

DOI:10.1039/c7ob01899a

Reference yield:

2-nitro-5-(trifluoromethyl)aniline (402-14-2) → 4-(trifluoromethyl)-1,2-phenylenediamine (368-71-8)

Guidance literature:

With methanol; palladium on activated charcoal; Hydrogenation;

DOI:10.1039/jr9500002792

upstream raw materials:

2-nitro-5-(trifluoromethyl)aniline

4-trifluoromethyl-2-nitroaniline

water

4-ethyl-2-nitroaniline

Downstream raw materials:

2-Methyl-5-trifluormethyl-benzimidazol

2,3-dimethyl-6-(trifluoromethyl)quinoxaline

2,3-diphenyl-6-(trifluoromethyl)quinoxaline

3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one