2-Methyl-4-oxo-7-(propan-2-yl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid

Base Information

• Chemical Name: 2-Methyl-4-oxo-7-(propan-2-yl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
• CAS No.: 67637-71-2
• Molecular Formula: C12H13NO3S
• Molecular Weight: 251.30200
• DSSTox Substance ID: DTXSID70497842
• Wikidata: Q82347614

Synonyms:67637-71-2;7-(1-methylethyl)-4-oxo-2-methyl-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid;DTXSID70497842;AKOS015966410;2-Methyl-4-oxo-7-(propan-2-yl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid

Chemical Property of 2-Methyl-4-oxo-7-(propan-2-yl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.93E-07mmHg at 25°C
• Boiling Point: 409.5oC at 760 mmHg
• Flash Point: 201.5oC
• PSA: 87.54000
• Density: 1.356g/cm3
• LogP: 2.65050
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 251.06161445
• Heavy Atom Count: 17
• Complexity: 391

Purity/Quality:

7-(1-METHYLETHYL)-4-OXO-2-METHYL-4,7-DIHYDROTHIENO(2,3-B)PYRIDINE-5-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC2=C(S1)N(C=C(C2=O)C(=O)O)C(C)C

Technology Process of 2-Methyl-4-oxo-7-(propan-2-yl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid

There total 3 articles about 2-Methyl-4-oxo-7-(propan-2-yl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl N-(5-methyl-2-thienyl)aminomethylenemalonate (55502-88-0) → 7-isopropyl-2-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid (67637-71-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenyl ether / 0.5 h / Heating

2: aq. NaOH / 1 h / Heating

3: (i) K₂CO₃, DMF, (ii) /BRN= 741852/

With sodium hydroxide; In diphenylether;

Reference yield:

2-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester (55503-12-3) → 7-isopropyl-2-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid (67637-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 1 h / Heating

2: (i) K₂CO₃, DMF, (ii) /BRN= 741852/

With sodium hydroxide;

Reference yield:

isopropyl bromide (75-26-3) + 2-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid (55503-13-4) → 7-isopropyl-2-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid (67637-71-2)

Guidance literature:

Multistep reaction; (i) K₂CO₃, DMF, (ii) /BRN= 741852/;

upstream raw materials:

isopropyl bromide

2-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid

diethyl N-(5-methyl-2-thienyl)aminomethylenemalonate

2-methyl-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 67637-71-2 7-(1-METHYLETHYL)-4-OXO-2-METHYL-4,7-DIHYDROTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send