4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-2-hydroxybutyrophenone

Base Information

Chemical Name:4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-2-hydroxybutyrophenone
CAS No.:51037-48-0
Molecular Formula:C₂₁H₂₃ClFNO₃
Molecular Weight:391.87
Hs Code.:
DSSTox Substance ID:DTXSID10965318
Nikkaji Number:J67.445A

Synonyms:BRN 1510378;4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-2-hydroxybutyrophenone;1-(4-Fluorophenyl)-2-hydroxy-4-(4-hydroxy-4-(4-chlorophenyl)-1-piperidyl)-1-butanone;BUTYROPHENONE, 4-(4-(p-CHLOROPHENYL)-4-HYDROXYPIPERIDINO)-4'-FLUORO-2-HYDROXY-;51037-48-0;C21H23ClFNO3;DTXSID10965318;4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)-2-hydroxybutan-1-one;LS-48312;gamma-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluoro-alpha-hydroxybutyrophenone

Suppliers and Price of 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-2-hydroxybutyrophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-2-hydroxybutyrophenone

Chemical Property:

Vapor Pressure:7.22E-14mmHg at 25°C
Boiling Point:570.8°Cat760mmHg
Flash Point:299°C
Density:1.301g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:391.1350495
Heavy Atom Count:27
Complexity:482

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCC(C(=O)C3=CC=C(C=C3)F)O

Technology Process of 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-2-hydroxybutyrophenone

There total 4 articles about 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-2-hydroxybutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51037-74-2
1-p-fluorobenzoyl-1-bromo-3-chloro-propane

: 51037-48-0
1-(4-fluorophenyl)-2-hydroxy-4-<4-hydroxy-4-(4-chlorophenyl)-1-piperidyl>-1-butanone

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / methanol / 24 h / Ambient temperature

2: potassium iodide / toluene / 20 h / Heating

With potassium iodide; In methanol; toluene;

Reference yield:

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 51037-48-0
1-(4-fluorophenyl)-2-hydroxy-4-<4-hydroxy-4-(4-chlorophenyl)-1-piperidyl>-1-butanone

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / bromine, CaCO₃ / CHCl₃ / 8 h / Ambient temperature

2: 81 percent / methanol / 24 h / Ambient temperature

3: potassium iodide / toluene / 20 h / Heating

With bromine; calcium carbonate; potassium iodide; In methanol; chloroform; toluene;