2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)-

Base Information Edit

Chemical Name:2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)-
CAS No.:676566-79-3
Molecular Formula:C33H41NO5
Molecular Weight:531.692
Hs Code.:
Mol file:676566-79-3.mol

2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid,
4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-,
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester,
(1R,4S,5R)-

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Chemical Property of 2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)- Edit

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Technology Process of 2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)-

There total 2 articles about 2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-2-(phenylmethyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-39-0
benzyl bromide

: 676566-78-2
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

: 676566-79-3
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-2-benzyl-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

Guidance literature:: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

benzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1002/hlca.200390320

Reference yield:

: 676566-77-1
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-4-(methoxymethoxy)-2-[(4-methylphenyl)sulfonyl]-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

: 676566-79-3
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-2-benzyl-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / Na; naphthalene / 1,2-dimethoxy-ethane / 0.17 h / -78 °C

2.1: NaH / dimethylformamide / 0.08 h / 0 °C

2.2: 96 percent / dimethylformamide / 1 h / 0 °C

With naphthalene; sodium; sodium hydride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390320