2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)-

Base Information

Chemical Name:2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)-
CAS No.:676566-78-2
Molecular Formula:C26H35NO5
Molecular Weight:441.568
Hs Code.:

2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid,
4-(methoxymethoxy)-3-oxo-,
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester,
(1R,4S,5R)-

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Chemical Property of 2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)-

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Technology Process of 2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)-

There total 7 articles about 2-Azabicyclo[2.2.2]oct-7-ene-5-carboxylic acid, 4-(methoxymethoxy)-3-oxo-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1R,4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 676566-77-1
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-4-(methoxymethoxy)-2-[(4-methylphenyl)sulfonyl]-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

: 676566-78-2
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

Guidance literature:: With naphthalene; sodium; In 1,2-dimethoxyethane; at -78 ℃; for 0.166667h;
DOI:10.1002/hlca.200390320

Reference yield:

: 16867-04-2
dihydroxypyridine

: 676566-78-2
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / 1H-imidazole / dimethylformamide / 23 °C

2.1: MeLi / diethyl ether / 2 h / 0 °C

2.2: 82 percent / diethyl ether / 30 h / 23 °C

3.1: 98 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h / 23 °C

4.1: quinine / CH₂Cl₂ / 72 h / 25 °C

5.1: 90 percent / P₂O₅ / CHCl₃ / 1 h / 25 °C

6.1: 81 percent / Na; naphthalene / 1,2-dimethoxy-ethane / 0.17 h / -78 °C

With 1H-imidazole; naphthalene; boron trifluoride diethyl etherate; methyllithium; sodium; phosphorus pentoxide; Quinine; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390320

Reference yield:

: 72526-00-2
(-)-8-phenylmenthyl acrylate

: 676566-78-2
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R,4S,5R)-4-(methoxymethoxy)-3-oxo-2-azabicyclo[2.2.2]oct-7-ene-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: quinine / CH₂Cl₂ / 72 h / 25 °C

2: 90 percent / P₂O₅ / CHCl₃ / 1 h / 25 °C

3: 81 percent / Na; naphthalene / 1,2-dimethoxy-ethane / 0.17 h / -78 °C

With naphthalene; sodium; phosphorus pentoxide; Quinine; In 1,2-dimethoxyethane; dichloromethane; chloroform;
DOI:10.1002/hlca.200390320