7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione

Base Information

Chemical Name:7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione
CAS No.:676596-64-8
Molecular Formula:C15H13BrN4O
Molecular Weight:345.19400
Hs Code.:
Mol file:676596-64-8.mol

Synonyms:9-[2-(4-bromophenyl)hydrazinyl]-7,8-dihydropyrido[3,2-b]azepin-6-one;

Suppliers and Price of 7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione
100mg
$ 1110.00

Total 3 raw suppliers

Chemical Property of 7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione

Chemical Property:

Melting Point:213-217°C
PSA：69.87000
Density:1.589g/cm3
LogP:3.55070
Storage Temp.:Refrigerator
Solubility.:DMSO, Methanol

Purity/Quality:

97% ^*data from raw suppliers

7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses A GSK-3 inhibitor; use to maintain potency of cultured multipotent non-embryonic progenitor cells. An intermediate of 1-Azakenpaullone and other Kenpaullone derivatives. 7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione is a GSK-3 inhibitor.

Technology Process of 7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione

There total 5 articles about 7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 589-21-9
(4-bromophenyl)hydrazine

: 676596-63-7
5H-pyrido[3,2-b]azepine-6,9(7H,8H)-dione

: 676596-64-8
9-[(4-bromo-phenyl)-hydrazono]-5,7,8,9-tetrahydro-pyrido[3,2-b]azepin-6-one

Guidance literature:: With hydrogenchloride; sodium acetate; In acetic acid; at 70 ℃;
DOI:10.1016/j.bmcl.2003.10.062

Reference yield:

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 676596-63-7
5H-pyrido[3,2-b]azepine-6,9(7H,8H)-dione

: 676596-64-8
9-[(4-bromo-phenyl)-hydrazono]-5,7,8,9-tetrahydro-pyrido[3,2-b]azepin-6-one

Guidance literature:: With sodium acetate; acetic acid; at 70 ℃;
DOI:10.1021/jm701582f

Reference yield:

: 27507-15-9
ethyl 3-aminopyridine-2-carboxylate

: 676596-64-8
9-[(4-bromo-phenyl)-hydrazono]-5,7,8,9-tetrahydro-pyrido[3,2-b]azepin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / pyridine / toluene / 2 h / Heating

2: 43 percent / KH / toluene; dimethylformamide / 70 °C

3: 95 percent / H₂O / dimethylformamide / 150 °C

4: 75 percent / HCl; NaOAc / acetic acid / 70 °C

With pyridine; hydrogenchloride; water; sodium acetate; potassium hydride; In acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2003.10.062