3-Aminopyridine-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-Aminopyridine-2-carboxylic acid ethyl ester
• CAS No.: 27507-15-9
• Molecular Formula: C8H10 N2 O2
• Molecular Weight: 166.18
• Hs Code.: 2933399090
• Mol file: 27507-15-9.mol

Synonyms:Picolinicacid, 3-amino-, ethyl ester (8CI); 3-Amino-2-(ethoxycarbonyl)pyridine;3-Aminopyridine-2-carboxylic acid ethyl ester; Ethyl 3-amino-2-picolinate;Ethyl 3-aminopicolinate; Ethyl 3-aminopyridine-2-carboxylate

Chemical Property of 3-Aminopyridine-2-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0.000219mmHg at 25°C
• Melting Point: 131-133 °C
• Refractive Index: 1.558
• Boiling Point: 326.2°Cat760mmHg
• PKA: 2.79±0.10(Predicted)
• Flash Point: 151.1°C
• PSA: 65.21000
• Density: 1.192g/cm³
• LogP: 1.42170
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97%+ ^*data from raw suppliers

Ethyl3-Aminopyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A synthetic intermediate for the synthesis of Kenpaullone derivatives, Cannabinoid receptor ligands, and nociceptive agents.

Technology Process of 3-Aminopyridine-2-carboxylic acid ethyl ester

There total 3 articles about 3-Aminopyridine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

ethanol (64-17-5) + 3-amino-pyridine-2-carboxylic acid (1462-86-8) → ethyl 3-aminopyridine-2-carboxylate (27507-15-9)

Guidance literature:

With sulfuric acid; for 48h; Heating;

DOI:10.1021/jo030017a

Reference yield:

pyridin-3-ylamine (462-08-8) + 2-oxo-propionic acid ethyl ester (617-35-6) → ethyl 3-aminopyridine-2-carboxylate (27507-15-9) + ethyl 3-amino-pyridine-6-carboxylate (119830-47-6) + Ethyl 3-Amino-6-carbethoxypicolinate (119830-48-7)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; Yield given. Multistep reaction. Yields of byproduct given; 1.) 0-5 deg C, water;

DOI:10.1007/BF00479343

Reference yield:

→ ethyl 3-aminopyridine-2-carboxylate (27507-15-9)

Guidance literature:

upstream raw materials:

ethanol

3-amino-pyridine-2-carboxylic acid

pyridin-3-ylamine

2-oxo-propionic acid ethyl ester

Downstream raw materials:

3-[(N-acetyl-sulfanilyl)-amino]-pyridine-2-carboxylic acid ethyl ester

3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<3,2-d>pyrimidine

1,5-naphthyridine-2,4-diol

3-[2-(2-Methoxy-phenyl)-acetylamino]-pyridine-2-carboxylic acid ethyl ester

Refernces

• 1、 -. "SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS". Page/Page column 154; 155. . Retrieved 2020/01/24.
• 2、 -. "PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS". Page/Page column 55. . Retrieved 2016/07/05.