676596-63-7

Upstream product

• 676596-62-6 9-hydroxy-6-oxo-6,7-dihydro-5H-pyrido[3,2-b]azepine-8-carboxylic acid ethyl ester 
• 676596-61-5 3-(3-ethoxycarbonyl-propionylamino)-pyridine-2-carboxylic acid ethyl ester 
• 27507-15-9 ethyl 3-aminopyridine-2-carboxylate 

Downstream Products

• 676596-64-8 9-[(4-bromo-phenyl)-hydrazono]-5,7,8,9-tetrahydro-pyrido[3,2-b]azepin-6-one 
• 914088-71-4 7,8-dihydro-5H-pyrido[3,2-b]azepine-6,9-dione 9-[(4-fluorophenyl)hydrazone] 
• 914088-75-8 7,8-dihydro-5H-pyrido[3,2-b]azepine-6,9-dione 9-(phenylhydrazone) 
• 1019995-22-2 3-iodo-4-[2-(6-oxo-5,6,7,8-tetrahydro-9H-pyrido[3,2-b]azepine-9-ylidene)hydrazino]benzonitrile 
• 914088-63-4 4-[2-(6-oxo-5,6,7,8-tetrahydro-9H-pyrido[3,2-b]azepine-9-ylidene)hydrazino]benzonitrile 
• 1019995-39-1 C₂₁H₁₅N₃O 
• 914088-66-7 7,8-dihydro-5H-pyrido[3,2-b]azepine-6,9-dione 9-[(4-chlorophenyl)hydrazone] 
• 1019995-38-0 C₂₂H₁₇N₃O 
• 914088-68-9 7,8-dihydro-5H-pyrido[3,2-b]azepine-6,9-dione 9-[(3,5-dichlorophenyl)hydrazone] 
• 1019995-21-1 C₁₅H₁₂F₂N₄O 
• 914088-80-5 7,8-dihydro-5H-pyrido[3,2-b]azepine-6,9-dione 9-[(4-iodophenyl)hydrazone] 
• 914088-78-1 7,8-dihydro-5H-pyrido[3,2-b]azepine-6,9-dione 9-{[4-(trifluoromethyl)phenyl]hydrazone} 
• 914088-61-2 4-[2-(6-oxo-5,6,7,8-tetrahydro-9H-pyrido[3,2-b]azepin-9-ylidene)hydrazino]benzoic acid 

Relevant academic research and scientific papers

9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) inhibitor activating pancreatic β cell protection and replication

Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator of pancreatic β cell growth and survival. On the basis of the previous observation that GSK-3 inhibitors like 1-azakenpaullone promote β cell protection and re

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β

Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3β versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3β selectivity of 1-azakenpaullone compared to other paullone derivatives.