Technology Process of 4-Hydroxy-3-methoxy-2-nitrobenzonitrile
There total 4 articles about 4-Hydroxy-3-methoxy-2-nitrobenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia; iodine;
In
tetrahydrofuran; water;
for 48h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; dmap / tetrahydrofuran / 2 h / 20 °C
2: nitric acid / 3 h / -10 - 0 °C
3: potassium hydroxide / water / 0.17 h / Reflux
4: ammonium hydroxide; iodine / tetrahydrofuran; water / 24 h / 20 °C
With
dmap; ammonium hydroxide; iodine; nitric acid; triethylamine; potassium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1021/jacs.5b03498
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium hydroxide / water / 0.17 h / Reflux
2: ammonium hydroxide; iodine / tetrahydrofuran; water / 24 h / 20 °C
With
ammonium hydroxide; iodine; potassium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1021/jacs.5b03498