(1,1-DIMETHYL-PROP-2-YNYL)-PHENYL-AMINE

Base Information

• Chemical Name: (1,1-DIMETHYL-PROP-2-YNYL)-PHENYL-AMINE
• CAS No.: 7471-09-2
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• Hs Code.: 2921420090
• Mol file: 7471-09-2.mol

Synonyms:3-methyl-3-phenylamino-1-butyne;

Chemical Property of (1,1-DIMETHYL-PROP-2-YNYL)-PHENYL-AMINE

Chemical Property:

• Vapor Pressure: 0.0109mmHg at 25°C
• Boiling Point: 262.4°Cat760mmHg
• Flash Point: 114.5°C
• PSA: 12.03000
• Density: 1.003g/cm³
• LogP: 2.58330

Purity/Quality:

99%min ^*data from raw suppliers

3-Methyl-3-phenylamino-1-butyne ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Methyl-3-phenylamino-1-butyne is an intermediate in the synthesis of Endophenazine A which is a new phenazine antibiotic isolated from the arthropod associated endosymbiont Streptomyces anulatus and shows antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).

Technology Process of (1,1-DIMETHYL-PROP-2-YNYL)-PHENYL-AMINE

There total 11 articles about (1,1-DIMETHYL-PROP-2-YNYL)-PHENYL-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-(propan-2-ylidene)aniline (1124-52-3) + acetylene (74-86-2,25067-58-7) → 3-methyl-3-phenylamino-1-butyne (7471-09-2)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 - 34 ℃; for 1h; under 1748.12 - 1976.13 Torr;

DOI:10.1002/ejoc.201900932

Reference yield: 82.0%

3-bromo-3-methylbut-1-yne (6214-31-9) + aniline (62-53-3) → 3-methyl-3-phenylamino-1-butyne (7471-09-2)

Guidance literature:

With copper(I) bromide; In acetonitrile; for 0.5h; Ambient temperature;

Reference yield: 79.0%

(3-chloro-3-methylbut-1-yn-1-yl)trimethylsilane (18387-63-8) + aniline (62-53-3) → 3-methyl-3-phenylamino-1-butyne (7471-09-2)

Guidance literature:

With copper bronze; water; copper; triethylamine; copper(l) iodide; In tetrahydrofuran; at 60 - 70 ℃; for 4h;

upstream raw materials:

3-chloro-3-methylbut-1-yne

aniline

3-bromo-3-methylbut-1-yne

1,1-dimethyl-2-propynyl acetate

Downstream raw materials:

quinoline

2,2-dimethyl-1,2-dihydroquinoline

2-(3-Hydroxy-3-methylbutyl)aniline

1,2,3,4-tetrahydro-2,2-dimethylquinolin-4-one

Refernces

• 1、 Schmidt, Elena Yu.,Bidusenko, Ivan A.,Protsuk, Nadezhda I.,Demyanov, Yan V.,Ushakov, Igor A.,Trofimov, Boris A.. "Superbase-Promoted Addition of Acetylene Gas to the C=N Bond". . p. 5875 - 5881. Retrieved 2019/09/10.
• 2、 -. "AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES". Page 21. . Retrieved 2010/11/30.