N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide

Base Information

• Chemical Name: N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide
• CAS No.: 92-72-8
• Molecular Formula: C19H16ClNO4
• Molecular Weight: 357.793
• Hs Code.: 2924299090
• European Community (EC) Number: 202-182-9
• NSC Number: 50687
• UNII: 54VM13755B
• DSSTox Substance ID: DTXSID2059061
• Nikkaji Number: J73.262A
• Wikidata: Q27261238
• ChEMBL ID: CHEMBL1736314
• Mol file: 92-72-8.mol

Synonyms:2-Naphthanilide,5'-chloro-3-hydroxy-2',4'-dimethoxy- (6CI,7CI,8CI);1-(2',3'-Hydroxynaphthoylamino)-2,4-dimethoxy-5-chlorobenzene;2-Hydroxy-3-naphthalenecarboxylic acid-2',4'-dimethoxy-5'-chlorophenylamide;5'-Chloro-2-hydroxy-2',4'-dimethoxy-3-naphthanilide;Acco Naf-Sol AS-ITR;Acna Naphthol SS;Amanil NaphtholAS-ITR;Anarthol AS-ITR;Azoground ITR;Azoic Coupling Component 12;Azotol O;C.I. 37550;C.I. Azoic Coupling Component 12;Daito Grounder ITR;Hiltonaphthol AS-ITR;NSC 50687;NaphtanilideITR;Naphthoide ITR;Naphthol ITR;Naphtol AS-ITR;Napthol ASITR;Scarlet GBase;Ultrazol IX-ITR;

Chemical Property of N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide

Chemical Property:

• Appearance/Colour: Light grey homogeneous powder
• Vapor Pressure: 7.52E-10mmHg at 25°C
• Melting Point: 200 °C
• Refractive Index: 1.682
• Boiling Point: 480.3 °C at 760 mmHg
• PKA: 8.65±0.40(Predicted)
• Flash Point: 244.3 °C
• PSA: 67.79000
• Density: 1.371 g/cm³
• LogP: 4.54130
• Solubility.: soluble in Dimethylformamide
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 357.0767857
• Heavy Atom Count: 25
• Complexity: 463

Purity/Quality:

99% ^*data from raw suppliers

5'-Chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide >98.0%(HPLC)(N) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1NC(=O)C2=CC3=CC=CC=C3C=C2O)Cl)OC

Technology Process of N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide

There total 2 articles about N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2,4-dimethoxyaniline (97-50-7) + 3-Hydroxy-2-naphthoic acid (92-70-6) → 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide (92-72-8)

Guidance literature:

With toluene; phosphorus trichloride;

Reference yield:

→ 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide (92-72-8)

Guidance literature:

aus p-Rosanilin;

Reference yield: 62.0%

2-hydroxychalcone (644-78-0,42224-53-3,99618-45-8) + 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide (92-72-8) → C34H26ClNO5

Guidance literature:

With camphor-10-sulfonic acid; In toluene; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201301295

upstream raw materials:

5-chloro-2,4-dimethoxyaniline

3-Hydroxy-2-naphthoic acid

Downstream raw materials:

3-(5-chloro-2,4-dimethoxy-phenyl)-2-imino-2,3-dihydro-naphtho[2,3-e][1,3]oxazin-4-one