METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE

Base Information

• Chemical Name: METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE
• CAS No.: 4093-88-3
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.14
• Hs Code.: 2933399090
• Mol file: 4093-88-3.mol

Synonyms:Pyridine,2-(methylamino)-3-nitro- (7CI,8CI);2-(Methylamino)-3-nitropyridine;N-Methyl-3-nitropyridin-2-amine;

Chemical Property of METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE

Chemical Property:

• Vapor Pressure: 0.0025mmHg at 25°C
• Melting Point: 67-69 °C
• Refractive Index: 1.629
• Boiling Point: 287.3 °C at 760 mmHg
• PKA: 2.87±0.10(Predicted)
• Flash Point: 127.6 °C
• PSA: 70.74000
• Density: 1.343 g/cm³
• LogP: 1.62770
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-3-nitropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE

There total 11 articles about METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + methylamine (74-89-5) → 2-(methylamino)-3-nitropyridine (4093-88-3)

Guidance literature:

In 2-methoxy-ethanol; at 80 ℃; for 8h; Sealed tube;

DOI:10.1016/j.tetlet.2015.09.076

Reference yield: 98.5%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-(methylamino)-3-nitropyridine (4093-88-3)

Guidance literature:

With methylamine; In ethanol; water;

Reference yield: 71.0%

N-Methylformamide (123-39-7) + 2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-(methylamino)-3-nitropyridine (4093-88-3)

Guidance literature:

for 3h; Reflux; neat (no solvent);

DOI:10.1590/S0103-50532010000800005

upstream raw materials:

2-amino-3-nitropyridine

methyl iodide

2-Chloro-3-nitropyridine

methylamine

Downstream raw materials:

2-hydroxy-3-nitropyridine

methyl-nitro-(3-nitro-[2]pyridyl)-amine

methylamine

3-methyl-3H-imidazo[4,5-b]pyridin-2-amine

Refernces

• 1、 Dong, Yaxi,Breit, Bernhard. "Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes". supporting information. p. 6765 - 6769. Retrieved 2021/09/11.
• 2、 -. "5,10-Dihydropyrido-pyrazolo-triazine compounds and application thereof". Paragraph 0097; 0098; 0099. . Retrieved 2017/08/02.