Tioxamast

Base Information

• Chemical Name: Tioxamast
• CAS No.: 74531-88-7
• Molecular Formula: C14H14 N2 O4 S
• Molecular Weight: 306.34
• Mol file: 74531-88-7.mol

Synonyms:Aceticacid, [[4-(4-methoxyphenyl)-2-thiazolyl]amino]oxo-, ethyl ester (9CI); F 1865;Tioxamast

Chemical Property of Tioxamast

Chemical Property:

• PSA: 105.76000
• Density: 1.326g/cm³
• LogP: 2.39330

Purity/Quality:

95% ^*data from raw suppliers

TIOXAMAST 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tioxamast

There total 6 articles about Tioxamast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(4-methoxyphenyl)-1,3-thiazol-2-amine (2104-04-3) + oxalic acid diethyl ester (95-92-1) → ethyl-(4-paramethoxyphenyl-2-thiazolyl)-oxamate (74531-88-7)

Guidance literature:

With sodium ethanolate; In tetrahydrofuran; ethanol; for 1.5h; Ambient temperature;

DOI:10.1055/s-1991-26569

Reference yield: 85.0%

→ ethyl-(4-paramethoxyphenyl-2-thiazolyl)-oxamate (74531-88-7)

Guidance literature:

Reference yield: 82.0%

4-(4-methoxyphenyl)-1,3-thiazol-2-amine (2104-04-3) + Ethyl oxalyl chloride (4755-77-5) → ethyl-(4-paramethoxyphenyl-2-thiazolyl)-oxamate (74531-88-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 3h; Ambient temperature;

upstream raw materials:

4-(4-methoxyphenyl)-1,3-thiazol-2-amine

Ethyl oxalyl chloride

oxalic acid diethyl ester

4-(4-Methoxy-phenyl)-thiazol-2-ylamine; hydriodide

Downstream raw materials:

N-(4-paramethoxyphenyl-2-thiazolyl)oxamic acid