4-(4-Methoxyphenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)-1,3-thiazol-2-amine
• CAS No.: 2104-04-3
• Molecular Formula: C10H10N2OS
• Molecular Weight: 206.268
• Hs Code.: 2934100090
• European Community (EC) Number: 842-724-7
• UNII: 792VG4M5YM
• DSSTox Substance ID: DTXSID90175251
• Nikkaji Number: J580.612G
• Wikidata: Q72518004
• ChEMBL ID: CHEMBL1444417
• Mol file: 2104-04-3.mol

Synonyms:2104-04-3;4-(4-Methoxyphenyl)-1,3-thiazol-2-amine;4-(4-methoxyphenyl)thiazol-2-amine;2-Amino-4-(4-methoxyphenyl)thiazole;2-Thiazolamine, 4-(4-methoxyphenyl)-;2-Amino-4-(p-methoxyphenyl)thiazole;2-Amino-4-(4-methoxyphenyl)-1,3-thiazole;4-(4-Methoxy-phenyl)-thiazol-2-ylamine;Thiazole, 2-amino-4-(p-methoxyphenyl)-;4-(4-Methoxyphenyl)-2-thiazolamine;MFCD00170663;4-(4-Methoxyphenyl)thiazol-2-ylamine;4-(4-methoxyphenyl)-1,3-thiazole-2-ylamine;SMR000146455;thiazol-2-amine, 6;Oprea1_246702;Oprea1_278956;Oprea1_844536;MLS000554138;MLS003675019;SCHEMBL127807;2-Amino-4-(p-anisyl)thiazole;792VG4M5YM;IFLab1_001098;CHEMBL1444417;BDBM31176;DTXSID90175251;HMS1415B20;HMS2568F06;STK346966;AKOS000115508;AKOS003245495;AB04278;CS-W018353;4(4-methoxy-phenyl)-thiazol-2-ylamine;IDI1_008965;4-(4-methoxyphenyl)-thiazol-2-yl-amine;NCGC00246266-01;Thiazol-2-amine, 4-(4-methoxyphenyl)-;LS-150782;BB 0218530;EU-0050983;FT-0677135;2-Amino-4-(4'-methoxyphenyl)-1,3-thiazole;EN300-02244;4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-imine;4T-0907;AB-601/30965017;SR-01000510845;J-013790;J-513540;SR-01000510845-1;4-(4-methoxy-phenyl)-thiazol-2-ylamine, AldrichCPR;AMINO-4-(4-METHOXYPHENYL)-1,3-THIAZOLE, 2-;Z48847512;F0370-0004

Chemical Property of 4-(4-Methoxyphenyl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.67E-06mmHg at 25°C
• Melting Point: 204-208 °C
• Refractive Index: 1.629
• Boiling Point: 396.7 °C at 760 mmHg
• PKA: 4.57±0.10(Predicted)
• Flash Point: 193.7 °C
• PSA: 76.38000
• Density: 1.259 g/cm³
• LogP: 2.98210
• Storage Temp.: 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 206.05138412
• Heavy Atom Count: 14
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Methoxyphenyl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CSC(=N2)N

Technology Process of 4-(4-Methoxyphenyl)-1,3-thiazol-2-amine

There total 24 articles about 4-(4-Methoxyphenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

thiourea (17356-08-0) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 4-(4-methoxyphenyl)-1,3-thiazol-2-amine (2104-04-3)

Guidance literature:

In ethanol; at 45 ℃; for 0.333333h; Sonication;

DOI:10.1007/s10895-015-1659-1

Reference yield: 97.0%

thiourea (17356-08-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 4-(4-methoxyphenyl)-1,3-thiazol-2-amine (2104-04-3)

Guidance literature:

With iodine; In ethanol; at 70 ℃; for 0.25h; Temperature; Time;

Reference yield: 90.0%

4-Methoxyphenylacetaldehyde (5703-26-4) + thiourea (17356-08-0) → 4-(4-methoxyphenyl)-1,3-thiazol-2-amine (2104-04-3)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 80 ℃; for 0.025h; Green chemistry;

DOI:10.1007/s11164-021-04630-4

upstream raw materials:

2-amino-4-(4'-methoxyphenyl)-5-bromothiazole

3-Allyl-2-[(Z)-4-(4-methoxy-phenyl)-thiazol-2-ylimino]-thiazolidin-4-one

2,2-dibromo-1-(4-methoxyphenyl)ethanone

thiourea

Downstream raw materials:

4-(4-methoxy-phenyl)-5-thiocyanato-thiazol-2-ylamine

4,4'-bis-(4-methoxy-phenyl)-5,5'-benzylidene-bis-thiazol-2-ylamine

N-acetyl-sulfanilic acid-[4-(4-methoxy-phenyl)-thiazol-2-ylamide]

2-{bis-[4-(4-methoxy-phenyl)-thiazol-2-ylamino]-methyl}-phenol

Refernces

• 1、 Aditya Rao, S. J.,Joy, Muthipeedika Nibin,Sukanya, S. H.,Venkatesh, Talavara. "Efficient L-Proline catalyzed synthesis of some new (4-substituted-phenyl)-1,5-dihydro-2H-pyrimido[4,5-d][1,3]thiazolo[3,2a]-pyrimidine-2,4(3H)-diones bearing thiazolopyrimidine derivatives and evaluation of their pharmacological activities". . . Retrieved 2022.
• 2、 Kalhor, Mehdi,Zarnegar, Zohre. "1-Methylimidazolium ionic liquid supported on Ni@zeolite-Y: fabrication and performance as a novel multi-functional nanocatalyst for one-pot synthesis of 2-aminothiazoles and 2-aryl benzimidazoles". . p. 519 - 540. Retrieved 2021/12/03.
• 3、 Gaidhane, Mahesh Krishanarao,Ghatole, Ajay Manohar,Hatzade, Kishor Manohar,Lanjewar, Kushal Radhesham. "In vitro anticancer activity of thiazole based β-amino carbonyl derivatives against HCT116 and H1299 colon cancer cell lines; study of pharmacokinetics, physicochemical, medicinal properties and molecular docking analysis". . p. 303 - 320. Retrieved 2021/09/28.