Broussonin B

Base Information

• Chemical Name: Broussonin B
• CAS No.: 73731-86-9
• Molecular Formula: C16H18O3
• Molecular Weight: 258.317
• Mol file: 73731-86-9.mol

Synonyms:

Chemical Property of Broussonin B

Chemical Property:

• PSA: 49.69000
• LogP: 3.28170

Purity/Quality:

98% ^*data from raw suppliers

BroussoninB ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Broussonin B

There total 4 articles about Broussonin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-4-(3-(4-(benzyloxy)-2-methoxyphenyl)allyl)phenol → 4-(3-(4-hydroxyphenyl)propyl)-3-methoxyphenol (73731-86-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 16.1667h;

DOI:10.3390/molecules200915966

Reference yield:

4-hydroxy-2-methoxybenzaldehyde (18278-34-7) → 4-(3-(4-hydroxyphenyl)propyl)-3-methoxyphenol (73731-86-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 1.5 h / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 0 °C / Inert atmosphere

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 16.17 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.3390/molecules200915966

Reference yield:

4-(benzyloxy)-2-methoxy-1-vinylbenzene (1286280-47-4) → 4-(3-(4-hydroxyphenyl)propyl)-3-methoxyphenol (73731-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 16.17 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.3390/molecules200915966

upstream raw materials:

4-hydroxy-2-methoxybenzaldehyde

4-(benzyloxy)-2-methoxybenzaldehyde

4-(benzyloxy)-2-methoxy-1-vinylbenzene

Downstream raw materials:

4-hydroxy-4-(3-(4-hydroxyphenyl)propyl)-3-methoxycyclohexa-2,5-dienone