4,14-Dioxa-3,15-disilaheptadecane, 5-[(2S,6R)-6-[(2R,5R)-5-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tri decyl]tetrahydro-2-furanyl]tetrahydro-2H-pyran-2-yl]-2,2,3,3,15,15,16,16 -octamethyl-13-[(phenylmethoxy)methyl]-, (5S,13R)-

Base Information

Chemical Name:4,14-Dioxa-3,15-disilaheptadecane, 5-[(2S,6R)-6-[(2R,5R)-5-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tri decyl]tetrahydro-2-furanyl]tetrahydro-2H-pyran-2-yl]-2,2,3,3,15,15,16,16 -octamethyl-13-[(phenylmethoxy)methyl]-, (5S,13R)-
CAS No.:681121-41-5
Molecular Formula:C57H110O6Si3
Molecular Weight:975.753
Hs Code.:

4,14-Dioxa-3,15-disilaheptadecane,
5-[(2S,6R)-6-[(2R,5R)-5-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tri
decyl]tetrahydro-2-furanyl]tetrahydro-2H-pyran-2-yl]-2,2,3,3,15,15,16,16
-octamethyl-13-[(phenylmethoxy)methyl]-, (5S,13R)-

Synonyms:

Suppliers and Price of 4,14-Dioxa-3,15-disilaheptadecane, 5-[(2S,6R)-6-[(2R,5R)-5-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tri decyl]tetrahydro-2-furanyl]tetrahydro-2H-pyran-2-yl]-2,2,3,3,15,15,16,16 -octamethyl-13-[(phenylmethoxy)methyl]-, (5S,13R)-

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Chemical Property of 4,14-Dioxa-3,15-disilaheptadecane, 5-[(2S,6R)-6-[(2R,5R)-5-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tri decyl]tetrahydro-2-furanyl]tetrahydro-2H-pyran-2-yl]-2,2,3,3,15,15,16,16 -octamethyl-13-[(phenylmethoxy)methyl]-, (5S,13R)-

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Technology Process of 4,14-Dioxa-3,15-disilaheptadecane, 5-[(2S,6R)-6-[(2R,5R)-5-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tri decyl]tetrahydro-2-furanyl]tetrahydro-2H-pyran-2-yl]-2,2,3,3,15,15,16,16 -octamethyl-13-[(phenylmethoxy)methyl]-, (5S,13R)-

There total 6 articles about 4,14-Dioxa-3,15-disilaheptadecane, 5-[(2S,6R)-6-[(2R,5R)-5-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tri decyl]tetrahydro-2-furanyl]tetrahydro-2H-pyran-2-yl]-2,2,3,3,15,15,16,16 -octamethyl-13-[(phenylmethoxy)methyl]-, (5S,13R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 681121-39-1
(1S,9R)-10-(benzyloxy)-9-(tert-butyldimethylsilyloxy)-1-[(2S,6R)-tetrahydro-6-[(2R,5R)-tetrahydro-5-[(R)-1-(tert-butyldimethylsilyloxy)tridecyl]furan-2-yl]-2H-pyran-2-yl]decan-1-ol

: 681121-41-5
(1S,9R)-10-(benzyloxy)-1-[(2S,6R)-tetrahydro-6-[(2R,5R)-tetrahydro-5-[(R)-1-(tert-butyldimethylsilyloxy)tridecyl]furan-2-yl]-2H-pyran-2-yl]-1,9-bis(tert-butyldimethylsilyloxy)decane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 10h;
DOI:10.1021/jo0303721

Reference yield:

: (Z)-(1R,14R)-15-Benzyloxy-14-(tert-butyl-dimethyl-silanyloxy)-1-{(R)-5-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-tridecyl]-tetrahydro-furan-2-yl}-pentadec-5-en-1-ol

: 681121-41-5
(1S,9R)-10-(benzyloxy)-1-[(2S,6R)-tetrahydro-6-[(2R,5R)-tetrahydro-5-[(R)-1-(tert-butyldimethylsilyloxy)tridecyl]furan-2-yl]-2H-pyran-2-yl]-1,9-bis(tert-butyldimethylsilyloxy)decane

Guidance literature:: Multi-step reaction with 6 steps

1: m-CPBA; Na₂HPO₄ / CH₂Cl₂ / 1.17 h / 20 °C

2: CSA / CH₂Cl₂ / 0.92 h / 20 °C

3: TPAP; 4 Angstroem molecular sieves; NMO / acetonitrile; CH₂Cl₂ / 2 h / 20 °C

4: 73 percent / K₂CO₃ / methanol; tetrahydrofuran / 5 h / 20 °C

5: 93 percent / Zn(BH₄)2 / CH₂Cl₂; hexane / 1 h / -78 - 0 °C

6: 98 percent / imidazole / dimethylformamide / 10 h / 20 °C

With 1H-imidazole; disodium hydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; zinc(II) tetrahydroborate; 4 A molecular sieve; camphor-10-sulfonic acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo0303721

Reference yield:

: (R)-4-{3-[(R)-9-Benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-nonyl]-oxiranyl}-1-{(R)-5-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-tridecyl]-tetrahydro-furan-2-yl}-butan-1-ol

: 681121-41-5
(1S,9R)-10-(benzyloxy)-1-[(2S,6R)-tetrahydro-6-[(2R,5R)-tetrahydro-5-[(R)-1-(tert-butyldimethylsilyloxy)tridecyl]furan-2-yl]-2H-pyran-2-yl]-1,9-bis(tert-butyldimethylsilyloxy)decane

Guidance literature:: Multi-step reaction with 5 steps

1: CSA / CH₂Cl₂ / 0.92 h / 20 °C

2: TPAP; 4 Angstroem molecular sieves; NMO / acetonitrile; CH₂Cl₂ / 2 h / 20 °C

3: 73 percent / K₂CO₃ / methanol; tetrahydrofuran / 5 h / 20 °C

4: 93 percent / Zn(BH₄)2 / CH₂Cl₂; hexane / 1 h / -78 - 0 °C

5: 98 percent / imidazole / dimethylformamide / 10 h / 20 °C

With 1H-imidazole; N-methyl-2-indolinone; tetrapropylammonium perruthennate; zinc(II) tetrahydroborate; 4 A molecular sieve; camphor-10-sulfonic acid; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo0303721