Technology Process of 4-Morpholinecarboxylic acid,
3-[(1-methylcyclopropyl)methyl]-2-oxo-5,6-diphenyl-, 1,1-dimethylethyl
ester, (3R,5R,6S)-
There total 2 articles about 4-Morpholinecarboxylic acid,
3-[(1-methylcyclopropyl)methyl]-2-oxo-5,6-diphenyl-, 1,1-dimethylethyl
ester, (3R,5R,6S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-Methyl-N'-nitro-N-nitrosoguanidine;
With
potassium hydroxide;
In
diethyl ether; water;
at 0 ℃;
for 0.0833333h;
tert-butyl (3R,5R,6S)-3-(2-methylprop-2-enyl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate;
palladium diacetate;
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
DOI:10.1016/j.bmc.2006.06.040
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 46 percent / tetrahydrofuran / -78 - 20 °C
2.1: KOH / H2O; diethyl ether / 0.08 h / 0 °C
2.2: 86 percent / Pd(OAc)2 / tetrahydrofuran; diethyl ether / 0 °C
With
potassium hydroxide; sodium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1016/j.bmc.2006.06.040
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 86 percent / LiNH2 / ethanol; tetrahydrofuran / 0.17 h / -78 °C
2: 74 percent / 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; 1-hydroxy-7-aza-1H-benzotriazole; Huenig's base / dimethylformamide / 18 h / 20 °C / pH 6 - 8
With
1-hydroxy-7-aza-benzotriazole; lithium amide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.040
