Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[[[(3, 4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl][2-[[(9H-fluoren-9 -ylmethoxy)carbonyl]amino]ethyl]amino]acetyl]amino]-3-pyridinyl]methyl] -, phenylmethyl ester

Base Information

• Chemical Name: Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[[[(3, 4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl][2-[[(9H-fluoren-9 -ylmethoxy)carbonyl]amino]ethyl]amino]acetyl]amino]-3-pyridinyl]methyl] -, phenylmethyl ester
• CAS No.: 681430-80-8
• Molecular Formula: C₄₈H₄₇N₉O₁₁
• Molecular Weight: 925.955

Synonyms:

Chemical Property of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[[[(3, 4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl][2-[[(9H-fluoren-9 -ylmethoxy)carbonyl]amino]ethyl]amino]acetyl]amino]-3-pyridinyl]methyl] -, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[[[(3, 4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl][2-[[(9H-fluoren-9 -ylmethoxy)carbonyl]amino]ethyl]amino]acetyl]amino]-3-pyridinyl]methyl] -, phenylmethyl ester

There total 5 articles about Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[[[(3, 4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl][2-[[(9H-fluoren-9 -ylmethoxy)carbonyl]amino]ethyl]amino]acetyl]amino]-3-pyridinyl]methyl] -, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid (169396-92-3) + {(4-amino-pyridin-3-ylmethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester (681430-66-0) → {[4-(2-{[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-pyridin-3-ylmethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester (681430-80-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2004.01.026

Reference yield:

thymidyl acetic acid (20924-05-4) → {[4-(2-{[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-pyridin-3-ylmethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester (681430-80-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / EDC / dimethylformamide / 20 °C

2: 100 percent / HCl / dioxane / 0.75 h

3: 0.32 g / HATU; DIPEA / dimethylformamide / 20 °C

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.01.026

Reference yield:

4--3-pyridinecarboxaldehyde (116026-93-8) → {[4-(2-{[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-pyridin-3-ylmethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester (681430-80-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaOAc / ethanol / 0.5 h

1.2: 43 percent / NaBH₃CN / ethanol / 7 h

2.1: 78 percent / EDC / dimethylformamide / 20 °C

3.1: 100 percent / HCl / dioxane / 0.75 h

4.1: 0.32 g / HATU; DIPEA / dimethylformamide / 20 °C

With hydrogenchloride; sodium acetate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.01.026

upstream raw materials:

2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid

{(4-amino-pyridin-3-ylmethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester

thymidyl acetic acid

4--3-pyridinecarboxaldehyde

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