169396-92-3

Basic information

• Product Name: Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-
• Synonyms: Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-;{[2-(9H-Fluoren-9-ylMethoxycarbonylaMino)-ethyl]-[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-acetyl]-aMino}-acetic acid;Fmoc-PNA-T-OH;Fmoc-PNA-thymine-OH;N-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethyl)-N-[(5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)acetyl]glycine;N-[2-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]glycine
• CAS NO: 169396-92-3
• Molecular Formula: C₂₆H₂₆N₄O₇
• Molecular Weight: 506.50724
• Mol File: 169396-92-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.368±0.06 g/cm3(Predicted)
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-(169396-92-3)
• EPA Substance Registry System: Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-(169396-92-3)

Safety Data

• Hazardous Substances Data: 169396-92-3(Hazardous Substances Data)

Usage

General Description

The chemical compound "Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-" is a synthetic derivative of glycine, which is a simple amino acid. Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]- contains various functional groups, including a pyrimidine ring, an acetyl group, and an amino group. It also contains a fluorenyl group, which is commonly used in protecting amino groups in peptide chemistry. The chemical structure suggests that it may have potential applications in medicinal chemistry and drug development. However, due to its complex nature, further research and analysis would be required to fully understand its properties and potential uses.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 139166-80-6 N-(2-t-butoxycarbonylaminoethyl)-N-(thymin-1-ylacetyl)glycine 
• 20924-05-4 thymidyl acetic acid 
• 172405-45-7 N-[2'-(N'-(9-fluorenylmethyloxycarbonyl)-amino)ethyl]glycine 
• 172405-62-8 methyl N-[2-(fluorenylmethoxycarbonyl)aminoethyl]-N-[(thymine-1-yl)acetyl]glycinate 
• 169396-88-7 tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride 
• 1378894-94-0 ethyl 2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetate 
• 172405-44-6 2-((2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)amino)acetic acid hydrochloride 
• 1378894-89-3 ethyl 2-((2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)amino)acetate hydrochloride 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 

Downstream Products

• 1227929-93-2 C₁₁₅H₁₅₀N₃₈O₄₀S 
• 681430-79-5 C₄₈H₅₂N₈O₁₃ 
• 681430-80-8 {[4-(2-{[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-pyridin-3-ylmethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester 

Relevant articles and documents

Peptide nucleic acid monomers: A convenient and efficient synthetic approach to Fmoc/Boc monomers

A convenient and cost-effective method for the synthesis of Fmoc/Boc-protected peptide nucleic acid monomers is described. The Fmoc/Boc strategy was developed in order to eliminate the solubility issues during peptide nucleic acid solid-phase synthesis, in particular that of the cytosine monomer, that occurred when using the commercialized Bhoc chemistry approach.

Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers.

Continuous advancement of application of peptide nucleic acid (PNA) oligomers encouraged exploration of rapid and efficient synthesis of PNA monomers and oligomers. Among the PNA monomers developed, only a few are commonly used in automated PNA synthesis.

Peptide nucleic acid based guanidinium compounds

Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may include peptide nucleic acid monomer units.