3-(2,4-Dichlorophenyl)-5-formylisoxazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:3-(2,4-Dichlorophenyl)-5-formylisoxazole-4-carboxylic acid methyl ester
CAS No.:682352-77-8
Molecular Formula:C12H7Cl2NO4
Molecular Weight:300.098
Hs Code.:
DSSTox Substance ID:DTXSID701181660
Nikkaji Number:J2.023.289G

Synonyms:DTXSID701181660;Methyl 3-(2,4-dichlorophenyl)-5-formyl-4-isoxazolecarboxylate;3-(2,4-Dichlorophenyl)-5-formylisoxazole-4-carboxylic acid methyl ester;682352-77-8

Suppliers and Price of 3-(2,4-Dichlorophenyl)-5-formylisoxazole-4-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2,4-Dichlorophenyl)-5-formylisoxazole-4-carboxylic acid methyl ester

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:298.9752131
Heavy Atom Count:19
Complexity:355

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(ON=C1C2=C(C=C(C=C2)Cl)Cl)C=O

Technology Process of 3-(2,4-Dichlorophenyl)-5-formylisoxazole-4-carboxylic acid methyl ester

There total 4 articles about 3-(2,4-Dichlorophenyl)-5-formylisoxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 682352-74-5
3-(2,4-dichloro-phenyl)-5-hydroxymethyl-isoxazole-4-carboxylic acid methyl ester

: 682352-77-8
3-(2,4-dichloro-phenyl)-5-formyl-isoxazole-4-carboxylic acid methyl ester

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1016/j.tet.2004.01.009

Reference yield:

: 4402-77-1
3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester

: 682352-77-8
3-(2,4-dichloro-phenyl)-5-formyl-isoxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NBS / CCl₄ / 40 h / 40 - 45 °C / UV-irradiation

1.2: 79 percent / H₂O / dimethylsulfoxide / 4 h / 80 °C

2.1: 67 percent / PCC / CH₂Cl₂ / 10 h / 20 °C

With N-Bromosuccinimide; pyridinium chlorochromate; In tetrachloromethane; dichloromethane;
DOI:10.1016/j.tet.2004.01.009