4-Isoxazolecarboxylic acid, 3-(2,4-dichlorophenyl)-5-methyl-, methyl ester

Base Information

• Chemical Name: 4-Isoxazolecarboxylic acid, 3-(2,4-dichlorophenyl)-5-methyl-, methyl ester
• CAS No.: 4402-77-1
• Molecular Formula: C12H9Cl2NO3
• Molecular Weight: 286.11100
• Hs Code.: 2934999090
• Mol file: 4402-77-1.mol

Synonyms:3-<2,4-Dichlor-benzyl>-sydnon;3-<2,4-Dichlor-phenyl>-5-methyl-isoxazol-4-carbonsaeure-methylester;

Chemical Property of 4-Isoxazolecarboxylic acid, 3-(2,4-dichlorophenyl)-5-methyl-, methyl ester

Chemical Property:

• PSA: 52.33000
• LogP: 3.74340

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isoxazolecarboxylic acid, 3-(2,4-dichlorophenyl)-5-methyl-, methyl ester

There total 2 articles about 4-Isoxazolecarboxylic acid, 3-(2,4-dichlorophenyl)-5-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride (29203-60-9) + acetoacetic acid methyl ester (105-45-3) → 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester (4402-77-1)

Guidance literature:

acetoacetic acid methyl ester; With sodium methylate; In methanol;

2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride; In methanol; at 0 ℃; for 4h;

DOI:10.1055/s-2003-40204

Reference yield:

2,4-dichlorobenzaldeyhde (874-42-0) + acetoacetic acid methyl ester (105-45-3) → 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester (4402-77-1)

Guidance literature:

Multistep reaction; (i) NH₂OH, (ii) Cl₂, CHCl₃, (iii) /BRN= 506727/, MeOH;

DOI:10.1039/jr9650005976

Reference yield: 100.0%

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester (4402-77-1) → [3-(2,4-dichloro-phenyl)-5-methyl-isoxazol-4-yl]-methanol (1018545-27-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 40 ℃; for 1h;

DOI:10.1055/s-2003-40204

upstream raw materials:

2,4-dichlorobenzaldeyhde

acetoacetic acid methyl ester

2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride

Downstream raw materials:

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

[3-(2,4-dichloro-phenyl)-5-methyl-isoxazol-4-yl]-methanol

3-(2,4-dichloro-phenyl)-5-hydroxymethyl-isoxazole-4-carboxylic acid methyl ester

5-bromomethyl-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester