4402-77-1

Upstream product

• 29203-60-9 2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride 
• 105-45-3 acetoacetic acid methyl ester 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 4402-78-2 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 1018545-27-1 [3-(2,4-dichloro-phenyl)-5-methyl-isoxazol-4-yl]-methanol 
• 4402-79-3 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid amide 
• 635681-04-8 2-{acetoxy-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]methyl}acrylic acid methyl ester 
• 635681-09-3 acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester 
• 627882-18-2 2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylic acid methyl ester 
• 635680-66-9 2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile 
• 635680-06-7 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carbaldehyde 
• 682352-99-4 5-(benzylamino-methyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid 
• 682352-90-5 5-(benzylamino-methyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester 
• 682352-81-4 5-bromomethyl-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester 
• 682352-85-8 3-(2,4-dichloro-phenyl)-5-(hydroxyimino-methyl)-isoxazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Highly substituted isoxazoles: The Baylis-Hillman reaction of substituted 4-isoxazolecarbaldehydes and attempted cyclization to isoxazole-annulated derivatives

In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarbaldehydes, the reactions of substituted 4-isoxazolecarbaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annulated derivatives from these Baylis-Hillman adducts involving SNR′-SNAr substitution strategy are also described.