Glycine, N-[2-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]ethyl]-N-[[6- [[(4-methoxyphenyl)diphenylmethyl]amino]-9H-purin-9-yl]acetyl]-

Base Information

Chemical Name:Glycine, N-[2-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]ethyl]-N-[[6- [[(4-methoxyphenyl)diphenylmethyl]amino]-9H-purin-9-yl]acetyl]-
CAS No.:682753-01-1
Molecular Formula:C41H43N7O6
Molecular Weight:729.836
Hs Code.:

Glycine,
N-[2-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]ethyl]-N-[[6-
[[(4-methoxyphenyl)diphenylmethyl]amino]-9H-purin-9-yl]acetyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[2-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]ethyl]-N-[[6- [[(4-methoxyphenyl)diphenylmethyl]amino]-9H-purin-9-yl]acetyl]-

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Technology Process of Glycine, N-[2-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]ethyl]-N-[[6- [[(4-methoxyphenyl)diphenylmethyl]amino]-9H-purin-9-yl]acetyl]-

There total 7 articles about Glycine, N-[2-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]ethyl]-N-[[6- [[(4-methoxyphenyl)diphenylmethyl]amino]-9H-purin-9-yl]acetyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 864776-34-1
methyl N-{2-[N'⁶-(4-methoxytrityl)-adenin-9-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycinate

: 682753-01-1
N-{2-[N'⁶-(4-methoxytrityl)-adenin-9-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycine

Guidance literature:: With caesium carbonate; In methanol; for 1.5h;
DOI:10.1016/j.tet.2005.06.003

Reference yield:

: 94142-97-9
2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione

: 682753-01-1
N-{2-[N'⁶-(4-methoxytrityl)-adenin-9-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycine

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / N,N-diisopropyl-N-ethylamine / CH₂Cl₂; methanol / 16 h / 20 °C

2: bromo-tris-pyrrolidino-phosphonium hexafluorophosphate; N,N-diisopropyl-N-ethyl / dimethylformamide / 2 h / 25 °C

3: 45 percent / aq. Cs₂CO₃ / methanol / 1.5 h

With N,N-diisopropyl-N-ethyl; caesium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.06.003

Reference yield:

: 861857-04-7
methyl N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)-ethylamino]-ethyl}-glycinate

: 682753-01-1
N-{2-[N'⁶-(4-methoxytrityl)-adenin-9-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycine

Guidance literature:: Multi-step reaction with 2 steps

1: bromo-tris-pyrrolidino-phosphonium hexafluorophosphate; N,N-diisopropyl-N-ethyl / dimethylformamide / 2 h / 25 °C

2: 45 percent / aq. Cs₂CO₃ / methanol / 1.5 h

With N,N-diisopropyl-N-ethyl; caesium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.06.003