1,3-Di(pyridin-2-yl)urea

Base Information

• Chemical Name: 1,3-Di(pyridin-2-yl)urea
• CAS No.: 6268-43-5
• Molecular Formula: C11H10 N4 O
• Molecular Weight: 214.227
• Hs Code.: 2933399090
• European Community (EC) Number: 228-442-1
• NSC Number: 36257
• UNII: L4Z49NN63K
• DSSTox Substance ID: DTXSID60211736
• Nikkaji Number: J31.401C
• Wikidata: Q72469508
• ChEMBL ID: CHEMBL3769824
• Mol file: 6268-43-5.mol

Synonyms:1,3-Di(pyridin-2-yl)urea;6268-43-5;1,3-dipyridin-2-ylurea;1,3-Di-2-pyridylurea;NSC36257;L4Z49NN63K;EINECS 228-442-1;NSC 36257;NSC-36257;dipyridylurea;n,n'-di-2-pyridylurea;1,3-bis(2-pyridyl)urea;1,3-Bis(2-pyridinyl)urea;N,N'-Di(2-pyridinyl)urea;UNII-L4Z49NN63K;SCHEMBL9750118;Urea, N,N'-di-2-pyridinyl-;CHEMBL3769824;FOQXHWCMYZXOGZ-UHFFFAOYSA-;DTXSID60211736;N,N'-DI-2-PYRIDINYLUREA;1,3-DI(2-PYRIDYL)UREA;N,N'-BIS(2-PYRIDYL)UREA;AM9789;MFCD00233705;1,3-BIS(PYRIDIN-2-YL)UREA;UREA, 1,3-DI-2-PYRIDYL-;AKOS016009643;DS-12075;CS-0149844;A868398

Chemical Property of 1,3-Di(pyridin-2-yl)urea

Chemical Property:

• Vapor Pressure: 0.0012mmHg at 25°C
• Boiling Point: 299.3°C at 760 mmHg
• Flash Point: 134.8°C
• PSA: 66.91000
• Density: 1.37g/cm³
• LogP: 2.26660
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 214.08546096
• Heavy Atom Count: 16
• Complexity: 212

Purity/Quality:

97% ^*data from raw suppliers

1,3-Di(pyridin-2-yl)urea 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NC(=O)NC2=CC=CC=N2

Technology Process of 1,3-Di(pyridin-2-yl)urea

There total 41 articles about 1,3-Di(pyridin-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-aminopyridine (504-29-0) + 2,2,2-trichloroethyl pyridazin-2-ylcarbamate (170961-14-5) → 1,3-di-pyridin-2-yl-urea (6268-43-5)

Guidance literature:

In tetrahydrofuran; at 100 ℃; for 72h; under 6000480 Torr;

DOI:10.1016/j.tetlet.2005.11.045

Reference yield: 96.0%

pyridine-2-carboxylic acid amide (1452-77-3) → 1,3-di-pyridin-2-yl-urea (6268-43-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In acetonitrile; at 80 ℃; for 4h; Temperature; Time; Sealed tube;

DOI:10.1039/d1nj03160k

Reference yield: 92.0%

2-aminopyridine (504-29-0) + 2H-<1,2,4>oxadiazolo<2,3-a>pyridine-2-thione (65478-59-3) → 1,3-di-pyridin-2-yl-urea (6268-43-5)

Guidance literature:

In dimethyl sulfoxide; at 80 - 90 ℃; for 2h;

DOI:10.1248/cpb.28.3570

upstream raw materials:

2-aminopyridine

phosgene

urea

N-(Pyridin-2-yl)urea

Downstream raw materials:

di-[2]pyridyl-carbodiimide

2-aminopyridine

3-propyl-1-(pyridin-2-yl)urea

1,3-dipropylurea