2,3-Epoxypropyltrimethylammonium chloride

Base Information

• Chemical Name: 2,3-Epoxypropyltrimethylammonium chloride
• CAS No.: 3033-77-0
• Deprecated CAS: 129829-22-7
• Molecular Formula: C6H14ClNO
• Molecular Weight: 151.636
• Hs Code.: 29239000
• European Community (EC) Number: 221-221-0,695-254-8
• ICSC Number: 1668
• NSC Number: 51213
• UNII: 283XH39M8X
• DSSTox Substance ID: DTXSID1044643
• Wikidata: Q2939557
• ChEMBL ID: CHEMBL3187272
• Mol file: 3033-77-0.mol

Synonyms:(2,3-Epoxypropyl)trimethylammoniumchloride (7CI);Oxiranemethanaminium, N,N,N-trimethyl-, chloride (9CI);(b,g-Epoxypropyl)trimethylammonium chloride;1,2-Epoxy-3-(trimethylammonio)propyl chloride;1-(Trimethylammonio)-2,3-epoxypropane chloride;Catiomaster G;ETA (oniumcompound);G-MAC;Glycidyltrimethylammonium chloride;Glytac A;GlytacA 100;N-Glycidyl-N,N,N-trimethylammonium chloride;N-Glycidyltrimethylammoniumchloride;QUAB 151;Raisacat 151;Trimethylglycidylammonium chloride;Weisstex E 100;Wildye PTC;[(Trimethylammonio)methyl]oxiranechloride;

Chemical Property of 2,3-Epoxypropyltrimethylammonium chloride

Chemical Property:

• Appearance/Colour: solid
• Melting Point: 137-139 °C
• Refractive Index: 1.48
• Flash Point: 170 °C
• PSA: 12.53000
• Density: 1.13 g/mL at 20 °C(lit.)
• LogP: -2.90460
• Storage Temp.: 2-8°C
• Solubility.: Methanol (Slightly), Water (Sparingly)
• Water Solubility.: 852g/L at 20℃
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 151.0763918
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

99% min ^*data from raw suppliers

GlycidyltrimethylammoniumChloride(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 45-21/22-41-43-48/22-68-52/53-20/21/22-60
• Safety Statements: 53-14-26-36/37/39-45-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Quaternary Amines
• Canonical SMILES: C[N+](C)(C)CC1CO1.[Cl-]
• Inhalation Risk: Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes and respiratory tract.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
• Description: Used in the production of cationic starch for the paper industry, 2,3-Epoxypropyl trimethyl ammonium chloride (EPTMAC) caused contact dermatitis in the workers.
• Uses: Reagent used for synthesis and antimicrobial activity of a water soluble chitosan derivative with a fiber-reactive group. Glycidyltrimethylammonium chloride be used as a derivatizing agent to synthesize N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), a water-soluble chitosan derivative, by reacting with chitosan. HTCC can form nanocomposite films with silver nanoparticles that show good antimicrobial property and optical transparency. Cationic starches can also be prepared by derivatization of starch with GTMAC.

Technology Process of 2,3-Epoxypropyltrimethylammonium chloride

There total 4 articles about 2,3-Epoxypropyltrimethylammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride (101396-91-2,117604-42-9) → glycidyltrimethylammonium chloride (3033-77-0)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.5h;

Reference yield:

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) + trimethylamine (75-50-3) → glycidyltrimethylammonium chloride (3033-77-0)

Guidance literature:

With ethanol; at 100 ℃;

Reference yield:

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → glycidyltrimethylammonium chloride (3033-77-0)

Guidance literature:

upstream raw materials:

epichlorohydrin

trimethylamine

N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride

Downstream raw materials:

2-Hydroxy-3-(4-(4-methylbenzoyl)phenoxy)-N,N,N-trimethyl-1-propanaminium chloride

2-Hydroxy-3-(2-benzoylphenoxy)-N,N,N-trimethyl-1-propanaminium chloride

(Z)-2-hydroxy-3-[(1-oxo-9-octadecenyl)oxy]propyltrimethylammonium chloride

2-Hydroxy-3-(3-benzoylphenoxy)-N,N,N-trimethyl-1-propanaminium chloride

Refernces

• 1、 Fan, Lihong,Cao, Mi,Gao, Song,Wang, Weiping,Peng, Kai,Tan, Chang,Wen, Feng,Tao, Shengxiang,Xie, Weiguo. "Preparation and characterization of a quaternary ammonium derivative of pectin". . p. 707 - 712. Retrieved 2012.
• 2、 -. "Preparation method of quaternary ammonium salt GTMAC". Paragraph 0009. . Retrieved 2016/11/21.