(+)-Dropropizine

Base Information Edit

Chemical Name:(+)-Dropropizine
CAS No.:99291-24-4
Molecular Formula:C₁₃H₂₀N₂O₂
Molecular Weight:236.314
Hs Code.:
UNII:FS5K818KA7
DSSTox Substance ID:DTXSID101030215
Nikkaji Number:J1.459.111G
Wikidata:Q27278167
Mol file:99291-24-4.mol

Synonyms:(+)-Dropropizine;99291-24-4;(2R)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol;(R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol;(R)-(+)-Dropropizine;Dropropizine S-form;FS5K818KA7;1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (R)-;(2R)-3-(4-phenyl-1-piperazinyl)propane-1,2-diol;Dextrodropropizine;Levdropropizina;Levdropropizina [Latin,Spanish];BRN 3592398;UNII-FS5K818KA7;(R)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol;D-DROPROPIZINE;DROPROPIZINE, (R)-;5-23-02-00111 (Beilstein Handbook Reference);DROPROPIZINE, (+)-;SCHEMBL8379428;DROPROPIZINE R-FORM [MI];DTXSID101030215;AKOS016843682;DEXTRODROPROPIZINE [EP IMPURITY];SW219837-1;LEVODROPROPIZINE IMPURITY A [EP IMPURITY];A845990;EN300-18547000;Q27278167;(2R)-3-(4-PHENYL-1-PIPERAZINYL)-1,2-PROPANEDIOL;1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-, (2R)-

Suppliers and Price of (+)-Dropropizine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(+)-Dropropizine
1g
$ 1455.00

TRC
(R)-(+)-Dropropizine
100mg
$ 185.00

Sigma-Aldrich
Levodropropizine European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Levodropropizine impurity A European Pharmacopoeia (EP) Reference Standard
l0420002
$ 190.00

AvaChem
Dextrodropropizine
1g
$ 109.00

AvaChem
Dextrodropropizine
100mg
$ 59.00

American Custom Chemicals Corporation
(2R)-3-(4-PHENYL-1-PIPERAZINYL)-1,2-PROPANEDIOL 95.00%
1G
$ 1963.50

American Custom Chemicals Corporation
(2R)-3-(4-PHENYL-1-PIPERAZINYL)-1,2-PROPANEDIOL 95.00%
100MG
$ 750.75

American Custom Chemicals Corporation
(R)-(+)-DROPROPIZINE 95.00%
5MG
$ 501.17

AHH
Levodropropizine 98%
5g
$ 430.00

Total 49 raw suppliers

Chemical Property of (+)-Dropropizine Edit

Chemical Property:

Appearance/Colour:White or off white crystalline powder
Vapor Pressure:1.5E-07mmHg at 25°C
Melting Point:98-100°
Refractive Index:1.576
Boiling Point:412.7 °C at 760 mmHg
PKA:14.21±0.20(Predicted)
Flash Point:220.9 °C
PSA：46.94000
Density:1.168 g/cm³
LogP:0.16470
Storage Temp.:2-8°C
Solubility.:Acetonitrile (Slightly), Methanol (Slightly)
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:236.152477885
Heavy Atom Count:17
Complexity:212

Purity/Quality:

99% HPLC ^*data from raw suppliers

(R)-(+)-Dropropizine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CC(CO)O)C2=CC=CC=C2
Isomeric SMILES:C1CN(CCN1C[C@H](CO)O)C2=CC=CC=C2
Description Levodropropizine is an antitussive with antiinflammatory activity, the L-isomer of dropropizine. Compared with the racemate, levodropropizine is reported to have less sedative potential and better therapeutic index, while maintaining the the same efficacy levels as an antitussive and antiinflammatory.
Uses R-Form of Dropropizine (D681495). (R)-(+)-Dropropizine is a cough suppressive phenylpiperazine derivative. (R)-(+)-Dropropizine is an antitussive and central sedative therapeutic agent. receptor agonist, treatment of colds and allergic rhinitis

Technology Process of (+)-Dropropizine

There total 22 articles about (+)-Dropropizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%