1-Glycidyl-4-phenylpiperazine

Base Information

• Chemical Name: 1-Glycidyl-4-phenylpiperazine
• CAS No.: 72566-27-9
• Molecular Formula: C13H18 N2 O
• Molecular Weight: 218.299
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID00439997
• Nikkaji Number: J2.961.522E
• Mol file: 72566-27-9.mol

Synonyms:72566-27-9;1-glycidyl-4-phenylpiperazine;SCHEMBL3356592;DTXSID00439997;AKOS000158381;AG-G-85862;1-[(oxiran-2-yl)methyl]-4-phenylpiperazine;EN300-60265

Chemical Property of 1-Glycidyl-4-phenylpiperazine

Chemical Property:

• Vapor Pressure: 7.83E-05mmHg at 25°C
• Refractive Index: 1.58
• Boiling Point: 341.8°C at 760 mmHg
• Flash Point: 104.1°C
• PSA: 19.01000
• Density: 1.144g/cm³
• LogP: 1.21030
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 218.141913202
• Heavy Atom Count: 16
• Complexity: 220

Purity/Quality:

97% ^*data from raw suppliers

1-(2,3-EPOXYPROPYL)-4-PHENYLPIPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CC2CO2)C3=CC=CC=C3

Technology Process of 1-Glycidyl-4-phenylpiperazine

There total 3 articles about 1-Glycidyl-4-phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-phenyl-1-piperazine (92-54-6) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(1-phenyl-4-piperazino)-2,3-epoxypropane (72566-27-9)

Guidance literature:

With sodium hydroxide; In water; at 75 ℃; for 0.25h;

DOI:10.1002/cssc.202002267

Reference yield:

3-<4-Phenylpiperazinyl>-2-hydroxypropyl chloride (67568-57-4) → 1-(1-phenyl-4-piperazino)-2,3-epoxypropane (72566-27-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 15h; Ambient temperature;

DOI:10.1016/0223-5234(92)90177-3

Reference yield:

4-phenyl-1-piperazine (92-54-6) → 1-(1-phenyl-4-piperazino)-2,3-epoxypropane (72566-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / ethanol / 24 h / Ambient temperature

2: NaOH / ethanol / 15 h / Ambient temperature

With sodium hydroxide; In ethanol;

DOI:10.1016/0223-5234(92)90177-3

upstream raw materials:

3-<4-Phenylpiperazinyl>-2-hydroxypropyl chloride

4-phenyl-1-piperazine

epichlorohydrin

Downstream raw materials:

1-ethyl-5-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-3,4-dihydro-1H-quinolin-2-one

1-(2-(7-chloroquinolin-4-ylamino)ethylamino)-3-(4-phenylpiperazin-1-yl)propan-2-ol

3-(2-(7-chloroquinolin-4-ylamino)ethyl)-5-((4-phenylpiperazin-1-yl)methyl)oxazolidin-2-one

dropropizine