Technology Process of Propanedioic acid, [2-nitro-4-(phenylmethoxy)-1-naphthalenyl]-,
dimethyl ester
There total 8 articles about Propanedioic acid, [2-nitro-4-(phenylmethoxy)-1-naphthalenyl]-,
dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
malonic acid dimethyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
4-benzyloxy-1-chloro-2-nitronaphthalene;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 12h;
DOI:10.1021/jo035465x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 99 percent / MeOH; K2CO3 / 0.5 h / 0 °C
2.1: 92 percent / Bu4NI; K2CO3 / dimethylformamide / 1.25 h / 25 °C
3.1: 78 percent / NaOH / methanol / 3 h / 70 °C
4.1: 76 percent / BF3*OEt2; t-BuONO / 1,2-dimethoxy-ethane / 2 h / -15 - 0 °C
5.1: 75 percent / CuCl; CuCl2 / H2O; acetonitrile / 0 - 25 °C
6.1: NaH / dimethylformamide / 0.5 h / 0 °C
6.2: 86 percent / dimethylformamide / 12 h / 80 °C
With
methanol; sodium hydroxide; tert.-butylnitrite; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; copper(l) chloride; copper dichloride;
In
methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo035465x
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 78 percent / HNO3 / 1 h / 18 °C
2.1: 99 percent / MeOH; K2CO3 / 0.5 h / 0 °C
3.1: 92 percent / Bu4NI; K2CO3 / dimethylformamide / 1.25 h / 25 °C
4.1: 78 percent / NaOH / methanol / 3 h / 70 °C
5.1: 76 percent / BF3*OEt2; t-BuONO / 1,2-dimethoxy-ethane / 2 h / -15 - 0 °C
6.1: 75 percent / CuCl; CuCl2 / H2O; acetonitrile / 0 - 25 °C
7.1: NaH / dimethylformamide / 0.5 h / 0 °C
7.2: 86 percent / dimethylformamide / 12 h / 80 °C
With
methanol; sodium hydroxide; tert.-butylnitrite; boron trifluoride diethyl etherate; nitric acid; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; copper(l) chloride; copper dichloride;
In
methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo035465x
