1-Piperazinecarboxylic acid, 4-methyl-3-oxo-, phenylmethyl ester

Base Information

• Chemical Name: 1-Piperazinecarboxylic acid, 4-methyl-3-oxo-, phenylmethyl ester
• CAS No.: 685520-31-4
• Molecular Formula: C13H16N2O3
• Molecular Weight: 248.282
• Mol file: 685520-31-4.mol

Synonyms:

Chemical Property of 1-Piperazinecarboxylic acid, 4-methyl-3-oxo-, phenylmethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 4-methyl-3-oxo-, phenylmethyl ester

There total 2 articles about 1-Piperazinecarboxylic acid, 4-methyl-3-oxo-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzyloxycarbonylpiperazin-2-one (78818-15-2) + methyl iodide (74-88-4) → 4-methyl-3-oxopiperazine-1-carboxylic acid benzyl ester (685520-31-4)

Guidance literature:

4-benzyloxycarbonylpiperazin-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Cooling with ice;

Reference yield: 66.0%

methyl iodide (74-88-4) → 4-methyl-3-oxopiperazine-1-carboxylic acid benzyl ester (685520-31-4)

Guidance literature:

4-benzyloxycarbonylpiperazin-2-one; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield: 100.0%

4-methyl-3-oxopiperazine-1-carboxylic acid benzyl ester (685520-31-4) → 1-methylpiperazin-2-one (59702-07-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h;

upstream raw materials:

methyl iodide

4-benzyloxycarbonylpiperazin-2-one

Downstream raw materials:

1-methylpiperazin-2-one