Pharmakon1600-01500422

Base Information Edit

Chemical Name:Pharmakon1600-01500422
CAS No.:357-08-4
Molecular Formula:C19H22ClNO4
Molecular Weight:363.841
Hs Code.:
NSC Number:757109
Mol file:357-08-4.mol

Synonyms:MLS002320740;SCHEMBL782691;SPECTRUM1500422;HMS1920P09;Pharmakon1600-01500422;CCG-40123;NSC757109;SMR001338886;4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride

Suppliers and Price of Pharmakon1600-01500422

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Naloxone hydrochloride
100mg
$ 339.00

TRC
NaloxoneHydrochloride
1g
$ 250.00

Tocris
Naloxonehydrochloride ≥99%(HPLC)
100
$ 108.00

Medical Isotopes, Inc.
NaloxoneHCl
1 g
$ 1390.00

DC Chemicals
Naloxone(hydrochloride) >98%
1 g
$ 800.00

DC Chemicals
Naloxone(hydrochloride) >98%
100 mg
$ 200.00

Crysdot
Naloxonehydrochloride 98+%
100mg
$ 45.00

Crysdot
Naloxonehydrochloride 98+%
250mg
$ 85.00

Cayman Chemical
Naloxone (hydrochloride) ≥95%
250mg
$ 146.00

Cayman Chemical
Naloxone (hydrochloride) ≥95%
100mg
$ 98.00

Total 1 raw suppliers

Chemical Property of Pharmakon1600-01500422 Edit

Chemical Property:

Appearance/Colour:white to off-white powder
Vapor Pressure:3.49E-12mmHg at 25°C
Melting Point:200-205 °C
Boiling Point:532.8 °C at 760 mmHg
Flash Point:276.1 °C
PSA：70.00000
LogP:2.04130
Storage Temp.:2-8°C
Solubility.:ethanol: 3.3 mg/mL stable for several months refrigerated i
Water Solubility.:Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml) and dimethyl sulfoxide (73 mg/ml). Insoluble in ether
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:363.1237359
Heavy Atom Count:25
Complexity:594

Purity/Quality:

99% ^*data from raw suppliers

Naloxone hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 22-24/25-26-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl
Isomeric SMILES:C=CCN1CC[C@]23C4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
Description Naloxone (hydrochloride) (CRM) (Item No. ISO60191) is a certified reference material categorized as an opioid antagonist. Formulations containing naloxone have been used as antidotes for opioid overdose and the prevention of overdose. They have also been used in combination with buprenorphine (Item Nos. ISO60178 | 14025) in the treatment of opiate addiction and in pain management. This product is intended for research and forensic applications.
Uses Specific opioid antagonist. Narcotic antagonist Opioate antidote; A nonspecific opiate receptor antagonist that displays anitnociceptive effects Naloxone Hydrochloride is a specific opioid antagonist. Narcotic antagonist.
Therapeutic Function Narcotic antagonist
Clinical Use #N/A
Drug interactions Potentially hazardous interactions with other drugs None known

Technology Process of Pharmakon1600-01500422

There total 10 articles about Pharmakon1600-01500422 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 131830-09-6,70866-64-7
Naloxone methyl ether

: 357-08-4
naloxone hydrochloride

Guidance literature:: Naloxone methyl ether; With boron tribromide; In chloroform; at 15 ℃; for 3h;

With hydrogenchloride; boric acid; In ethanol; chloroform; water; at 85 ℃; Temperature;