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Oxycodone hydrochloride

Base Information Edit
  • Chemical Name:Oxycodone hydrochloride
  • CAS No.:124-90-3
  • Molecular Formula:C18H22ClNO4
  • Molecular Weight:351.83
  • Hs Code.:2939110000
  • European Community (EC) Number:204-717-1
  • DSSTox Substance ID:DTXSID80924674
  • Wikidata:Q27107601
  • NCI Thesaurus Code:C48010
  • RXCUI:82063
  • ChEMBL ID:CHEMBL1200890
  • Mol file:124-90-3.mol
Oxycodone hydrochloride

Synonyms:Dihydrohydroxycodeinone;Dihydrone;Dinarkon;Eucodal;Oxiconum;Oxycodeinon;Oxycodone;Oxycodone Hydrochloride;Oxycone;Oxycontin;Pancodine;Theocodin

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Oxycodone hydrochloride Edit
Chemical Property:
  • Appearance/Colour:White solid 
  • Vapor Pressure:7.02E-11mmHg at 25°C 
  • Melting Point:261-263 °C 
  • Boiling Point:501.6 °C at 760 mmHg 
  • Flash Point:257.1 °C 
  • PSA:59.00000 
  • Density:1.39 g/cm3 
  • LogP:1.78810 
  • Storage Temp.:2-8°C 
  • Solubility.:Freely soluble in water, sparingly soluble in anhydrous ethanol, practically insoluble in toluene. 
  • Water Solubility.:142.9g/L(temperature not stated) 
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:1
  • Exact Mass:351.1237359
  • Heavy Atom Count:24
  • Complexity:553
Safty Information:
  • Pictogram(s): HarmfulXn 
  • Hazard Codes:Xn,T,F 
  • Statements: 22-39/23/24/25-23/24/25-11 
  • Safety Statements: 36/37-45-16-7 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

  • Canonical SMILES:CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)OC)O4)O.Cl
  • Isomeric SMILES:CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O.Cl
  • Recent ClinicalTrials:Study Evaluating the Abuse Potential of NEURONTIN? in Healthy Non-drug Dependent, Recreational Opioid Users
  • Recent EU Clinical Trials:Influence of oxycodone on individuals taking an SSRI
  • Recent NIPH Clinical Trials:A phase 3 study for S-8117 (OTR) switched from oxycodone hydrochloride controlled-release tablets in patients with chronic pain
  • Description Oxycodone (hydrochloride) (Item No. 26513) is an analytical reference standard categorized as an opioid. Oxycodone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
  • Uses Controlled substance (opiate). Analgesic (narcotic)
  • Therapeutic Function Narcotic analgesic
  • Clinical Use Oxycodone is about equipotent with morphine, but because of the 3-OCH group, it has a much lower oral:parenteral dose ratio. Thus, oxycodone is used orally to treat severe to moderate pain. It is a drug as a single agent and when combined in strong analgesic mixtures. Oxycodone has a plasma half-life of approximately 4 hours and requires dosing every 4 to 6 hours.
  • Drug interactions Potentially hazardous interactions with other drugs Analgesics: possible opioid withdrawal with buprenorphine and pentazocine. Antibacterials: metabolism possibly increased by rifampicin; metabolism inhibited by telithromycin. Antidepressants: CNS excitation or depression with MAOIs - avoid; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics. Antifungals: concentration increased by voriconazole. Antihistamines: increased sedative effects with sedating antihistamines. Antipsychotics: enhanced hypotensive and sedative effects. Antivirals: concentration possibly increased by ritonavir. Dopaminergics: avoid with selegiline. Nalmefene: avoid concomitant use. Sodium oxybate: enhanced effect of sodium oxybate - avoid.
Technology Process of Oxycodone hydrochloride

There total 9 articles about Oxycodone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; acetic acid; In water; at 20 ℃; for 1.25h; Reagent/catalyst;

Reference yield: 85%

Guidance literature:
Guidance literature:
With hydrogenchloride; zinc; In methanol; water; at 20 ℃; for 3 - 4h; pH=2 - 6.5; Product distribution / selectivity;
Refernces Edit