Oxycodone hydrochloride

Base Information Edit

Chemical Name:Oxycodone hydrochloride
CAS No.:124-90-3
Molecular Formula:C18H22ClNO4
Molecular Weight:351.83
Hs Code.:2939110000
European Community (EC) Number:204-717-1
UNII:C1ENJ2TE6C
DSSTox Substance ID:DTXSID80924674
Wikidata:Q27107601
NCI Thesaurus Code:C48010
RXCUI:82063
ChEMBL ID:CHEMBL1200890
Mol file:124-90-3.mol

Synonyms:Dihydrohydroxycodeinone;Dihydrone;Dinarkon;Eucodal;Oxiconum;Oxycodeinon;Oxycodone;Oxycodone Hydrochloride;Oxycone;Oxycontin;Pancodine;Theocodin

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Oxycodone hydrochloride Edit

Chemical Property:

Appearance/Colour:White solid
Vapor Pressure:7.02E-11mmHg at 25°C
Melting Point:261-263 °C
Boiling Point:501.6 °C at 760 mmHg
Flash Point:257.1 °C
PSA：59.00000
Density:1.39 g/cm³
LogP:1.78810
Storage Temp.:2-8°C
Solubility.:Freely soluble in water, sparingly soluble in anhydrous ethanol, practically insoluble in toluene.
Water Solubility.:142.9g/L(temperature not stated)
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:351.1237359
Heavy Atom Count:24
Complexity:553

Purity/Quality:

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn,T,F
Statements: 22-39/23/24/25-23/24/25-11
Safety Statements: 36/37-45-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)OC)O4)O.Cl
Isomeric SMILES:CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O.Cl
Recent ClinicalTrials:Study Evaluating the Abuse Potential of NEURONTIN? in Healthy Non-drug Dependent, Recreational Opioid Users
Recent EU Clinical Trials:Influence of oxycodone on individuals taking an SSRI
Recent NIPH Clinical Trials:A phase 3 study for S-8117 (OTR) switched from oxycodone hydrochloride controlled-release tablets in patients with chronic pain
Description Oxycodone (hydrochloride) (Item No. 26513) is an analytical reference standard categorized as an opioid. Oxycodone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Uses Controlled substance (opiate). Analgesic (narcotic)
Therapeutic Function Narcotic analgesic
Clinical Use Oxycodone is about equipotent with morphine, but because of the 3-OCH group, it has a much lower oral:parenteral dose ratio. Thus, oxycodone is used orally to treat severe to moderate pain. It is a drug as a single agent and when combined in strong analgesic mixtures. Oxycodone has a plasma half-life of approximately 4 hours and requires dosing every 4 to 6 hours.
Drug interactions Potentially hazardous interactions with other drugs Analgesics: possible opioid withdrawal with buprenorphine and pentazocine. Antibacterials: metabolism possibly increased by rifampicin; metabolism inhibited by telithromycin. Antidepressants: CNS excitation or depression with MAOIs - avoid; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics. Antifungals: concentration increased by voriconazole. Antihistamines: increased sedative effects with sedating antihistamines. Antipsychotics: enhanced hypotensive and sedative effects. Antivirals: concentration possibly increased by ritonavir. Dopaminergics: avoid with selegiline. Nalmefene: avoid concomitant use. Sodium oxybate: enhanced effect of sodium oxybate - avoid.

Technology Process of Oxycodone hydrochloride

There total 9 articles about Oxycodone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%