Name: Naloxone hydrochloride
SKU: 357-08-4

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Basic Information

Molecular Structure:
CAS No.:	357-08-4
Name:	Naloxone hydrochloride

Formula:	C₁₉H₂₂ClNO₄
Molecular Weight:	363.841
Synonyms:	Morphinan-6-one,17-allyl-4,5a-epoxy-3,14-dihydroxy-,hydrochloride (8CI);Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5a)- (9CI);Normorphinone,N-allyl-7,8-dihydro-14-hydroxy-, hydrochloride (7CI);(-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride;(-)-Naloxonehydrochloride;EN 1530;EN 15304;N-Allyldihydro-14-hydroxynormorphinonehydrochloride;NIH 7890;Nalone;Nalonee;Narcan;Narcanti;l-Naloxone hydrochloride;
EINECS:	206-611-0
Melting Point:	200-205 °C
Boiling Point:	532.8 °C at 760 mmHg
Flash Point:	276.1 °C
Solubility:	ethanol: 3.3 mg/mL
Appearance:	white to off-white powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	22-24/25-26-36/37/39
PSA:	70.00000
LogP:	2.04130

Raw Materials

124-90-3

Downstream Products

465-65-6

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Specification

The Naloxone hydrochloride, with the CAS registry number 357-08-4, is also known as Naloxone HCl. It belongs to the product categories of Intermediates & Fine Chemicals; Pharmaceuticals; Opioid Receptor and Opioid-Like Receptor; Opioids. Its EINECS registry number is 206-611-0. This chemical's molecular formula is C₁₉H₂₂ClNO₄ and molecular weight is 363.83528. Its systematic name is called (5α)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one hydrochloride. This chemical's classification codes are Antagonist [to narcotics]; Drug / Therapeutic Agent; Human Data; Reproductive Effect. This chemical can be used as antagonists of narcotics analgesics. In addition, it can relieve narcotics analgesics caused by respiratory inhibition and addiction.

Physical properties of Naloxone hydrochloride: (1)ACD/LogP: 1.45; (2)#H bond acceptors: 5; (3)#H bond donors: 2; (4)#Freely Rotating Bonds: 4; (5)Flash Point: 276.1 °C; (6)Enthalpy of Vaporization: 85.12 kJ/mol; (7)Boiling Point: 532.8 °C at 760 mmHg; (8)Vapour Pressure: 3.49E-12 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl
(2)Isomeric SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
(3)InChI: InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
(4)InChIKey: RGPDIGOSVORSAK-STHHAXOLSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intravenous	13ug/kg (0.013mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	American Journal of Emergency Medicine. Vol. 7, Pg. 127, 1989.
mouse	LD50	intravenous	90mg/kg (90mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakkyoku. Pharmacy. Vol. 36, Pg. 655, 1985.
mouse	LD50	oral	> 1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakkyoku. Pharmacy. Vol. 36, Pg. 655, 1985.
mouse	LD50	subcutaneous	286mg/kg (286mg/kg)		Journal of Medicinal Chemistry. Vol. 20, Pg. 844, 1977.
mouse	LDLo	intraperitoneal	80mg/kg (80mg/kg)		Research Communications in Chemical Pathology and Pharmacology. Vol. 17, Pg. 255, 1977.
rat	LD50	intraperitoneal	239mg/kg (239mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 357, 1985.
rat	LD50	intravenous	107mg/kg (107mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakkyoku. Pharmacy. Vol. 36, Pg. 655, 1985.
rat	LD50	oral	> 1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakkyoku. Pharmacy. Vol. 36, Pg. 655, 1985.
rat	LD50	subcutaneous	500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakkyoku. Pharmacy. Vol. 36, Pg. 655, 1985.
women	TDLo	intravenous	32ug/kg/3M-C (0.032mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Annals of Emergency Medicine. Vol. 16, Pg. 1294, 1987.

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Specification