20-(HYDROXYMETHYL)PREGNA-1,4-DIEN-3-ONE

Base Information

• Chemical Name: 20-(HYDROXYMETHYL)PREGNA-1,4-DIEN-3-ONE
• CAS No.: 35525-27-0
• Molecular Formula: C22H32 O2
• Molecular Weight: 328.495
• Mol file: 35525-27-0.mol

Synonyms:20a-Hydroxymethylpregna-1,4-dien-3-one

Chemical Property of 20-(HYDROXYMETHYL)PREGNA-1,4-DIEN-3-ONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 178-184 °C
• Refractive Index: 1.5344 (estimate)
• Boiling Point: 466°Cat760mmHg
• PKA: 14.97±0.10(Predicted)
• Flash Point: 198.2°C
• PSA: 37.30000
• Density: 1.09g/cm³
• LogP: 4.53890
• Storage Temp.: Hormones

Purity/Quality:

98%,99%, ^*data from raw suppliers

20α-Hydroxymethylpregna-1,4-dien-3-one ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 20α-Hydroxymethylpregna-1,4-dien-3-one, is one of the derivatives of Progesterone (P755900),which is a steroid hormone produced by the corpus luteum. Progesterone is also implicated in the etiology of breast cancer.

Technology Process of 20-(HYDROXYMETHYL)PREGNA-1,4-DIEN-3-ONE

There total 1 articles about 20-(HYDROXYMETHYL)PREGNA-1,4-DIEN-3-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

cholesterol (57-88-5) → Androstenedione (63-05-8) + Androsta-1,4-diene-3,17-dione (897-06-3) + (20S)-20-hydroxymethylpregn-4-en-3-one (40736-33-2) + 24-norchol-4-ene-3,22-dione (80981-37-9) + 24-norchola-1,4-diene-3,22-dione (80981-38-0) + 22-hydroxy-23,24-bis-norchola-1,4-diene-3-one (35525-27-0)

Guidance literature:

Product distribution; degradation by the Mycobacterium mutant CCM 3528;

Reference yield: 86.0%

22-hydroxy-23,24-bis-norchola-1,4-diene-3-one (35525-27-0) → pregna-1,4-diene-3,20-dione (1162-54-5) + (20S)-3-oxopregna-1,4-diene-20-carboxaldehyde (81201-82-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 0.25h;

Reference yield: 73.0%

22-hydroxy-23,24-bis-norchola-1,4-diene-3-one (35525-27-0) → (20S)-3-oxopregna-1,4-diene-20-carboxylic acid (67516-56-7,71154-85-3,20248-18-4)

Guidance literature:

With chromium(VI) oxide; In acetone; at 8 ℃; for 0.5h;

upstream raw materials:

cholesterol

Downstream raw materials:

(20S)-3-oxopregna-1,4-diene-20-carboxylic acid

pregna-1,4-diene-3,20-dione

(20S)-3-oxopregna-1,4-diene-20-carboxaldehyde

(20S)-20-(p-Toluolsulfonyloxymethyl)pregna-1,5-dien-3-on