1-(2-CHLORO-4-NITROPHENYL)ETHAN-1-ONE

Base Information

• Chemical Name: 1-(2-CHLORO-4-NITROPHENYL)ETHAN-1-ONE
• CAS No.: 67818-41-1
• Molecular Formula: C8H6ClNO3
• Molecular Weight: 199.594
• Hs Code.: 2914700090
• Mol file: 67818-41-1.mol

Synonyms:1-(2-chloro-4-nitrophenyl)ethanone;

Chemical Property of 1-(2-CHLORO-4-NITROPHENYL)ETHAN-1-ONE

Chemical Property:

• Vapor Pressure: 0.00667mmHg at 25°C
• Melting Point: 43.0 to 47.0 °C
• Boiling Point: 270.9°Cat760mmHg
• Flash Point: 117.6°C
• PSA: 62.89000
• Density: 1.378g/cm³
• LogP: 2.97400
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Chloro-4-nitrophenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(2-Chloro-4-nitrophenyl)ethanone is used in the preparation of Propiconazole (P770100) as haptens in manufacture of antibodies with hybridomas for immunoassay.

Technology Process of 1-(2-CHLORO-4-NITROPHENYL)ETHAN-1-ONE

There total 6 articles about 1-(2-CHLORO-4-NITROPHENYL)ETHAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-chloro-4-nitrobenzoyl chloride (7073-36-1) + diethyl malonate (105-53-3) → 1-(2-chloro-4-nitrophenyl)ethanone (67818-41-1)

Guidance literature:

diethyl malonate; With triethylamine; magnesium chloride; In toluene; at 20 ℃; for 1.5h;

2-chloro-4-nitrobenzoyl chloride; In toluene; at 20 - 50 ℃; for 18h;

With water; In dimethyl sulfoxide; at 160 ℃; for 12h;

Reference yield:

C14H14ClNO7 → 1-(2-chloro-4-nitrophenyl)ethanone (67818-41-1)

Guidance literature:

With hydrogenchloride; In water; dimethyl sulfoxide; at 160 ℃; for 12h;

Reference yield:

2-chloro-4-nitrobenzoyl chloride (7073-36-1) + malonic acid dimethyl ester (108-59-8) → 1-(2-chloro-4-nitrophenyl)ethanone (67818-41-1)

Guidance literature:

malonic acid dimethyl ester; With triethylamine; magnesium chloride; In toluene; at 20 ℃; for 1.5h;

2-chloro-4-nitrobenzoyl chloride; In toluene; for 0.75h;

With water; In dimethyl sulfoxide; Heating;

DOI:10.1021/jm050458h

upstream raw materials:

3-Chloro-4-ethylnitrobenzene

2-chloro-4-nitrobenzoyl chloride

malonic acid dimethyl ester

diethyl malonate

Downstream raw materials:

2,2-Dibromo-1-(2-chloro-4-nitro-phenyl)-ethanone

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND METHODS OF USE". Paragraph 0189. . Retrieved 2015/03/16.
• 2、 Dai, Yujia,Guo, Yan,Frey, Robin R.,Ji, Zhiqin,Curtin, Michael L.,Ahmed, Asma A.,Albert, Daniel H.,Arnold, Lee,Arries, Shannon S.,Barlozzari, Teresa,Bauch, Joy L.,Bouska, Jennifer J.,Bousquet, Peter F.,Cunha, George A.,Glaser, Keith B.,Guo, Jun,Li, Junling,Marcotte, Patrick A.,Marsh, Kennan C.,Moskey, Maria D.,Pease, Lori J.,Stewart, Kent D.,Stoll, Vincent S.,Tapang, Paul,Wishart, Neil,Davidsen, Steven K.,Michaelides, Michael R.. "Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors". . p. 6066 - 6083. Retrieved 2007/10/03.