Methyl 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-3-(4-nitrophenyl)propanoate

Base Information

Chemical Name:Methyl 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-3-(4-nitrophenyl)propanoate
CAS No.:5472-61-7
Molecular Formula:C18H14N2O6
Molecular Weight:354.3136
Hs Code.:
NSC Number:29430
DSSTox Substance ID:DTXSID90283042
Nikkaji Number:J736.357E

Synonyms:5472-61-7;methyl 2-(1,3-dioxoisoindol-2-yl)-3-(4-nitrophenyl)propanoate;methyl 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-3-(4-nitrophenyl)propanoate;NSC29430;DTXSID90283042;NSC-29430

Suppliers and Price of Methyl 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-3-(4-nitrophenyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Methyl 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-3-(4-nitrophenyl)propanoate

Chemical Property:

Vapor Pressure:9.66E-12mmHg at 25°C
Boiling Point:540.3°C at 760 mmHg
Flash Point:280.6°C
Density:1.433g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:354.08518617
Heavy Atom Count:26
Complexity:569

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])N2C(=O)C3=CC=CC=C3C2=O

Technology Process of Methyl 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-3-(4-nitrophenyl)propanoate

There total 10 articles about Methyl 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-3-(4-nitrophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 67-56-1
methanol

: C₂₆H₂₈N₆O₅

: 5472-61-7
C₁₈H₁₄N₂O₆

Guidance literature:: With boron trifluoride diethyl etherate; at 100 ℃; for 10h;
DOI:10.1039/c5ob00066a

Reference yield: 86.0%

: 67-56-1
methanol

: 131175-70-7,5467-31-2
(R)-N-phthaloyl-p-nitrophenylalanine

: 178601-75-7,5472-61-7
(R)-N-phthaloyl-p-nitrophenylalanine methyl ester

Guidance literature:: With thionyl chloride; for 16h;
DOI:10.1016/0040-4020(96)00307-9

Reference yield:

: 85-44-9
phthalic anhydride

: 5472-61-7
C₁₈H₁₄N₂O₆

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / toluene / Reflux

2: thionyl chloride; N,N-dimethyl-formamide / 4 h / 82 °C

3: triethylamine / dichloromethane / 5 h / 0 - 20 °C

4: copper(II) sulfate; sodium L-ascorbate / acetone; water / 20 °C / Inert atmosphere

5: palladium diacetate; silver(I) acetate / 5 h / 100 °C / Sealed tube

6: boron trifluoride diethyl etherate / 10 h / 100 °C

With thionyl chloride; boron trifluoride diethyl etherate; silver(I) acetate; palladium diacetate; copper(II) sulfate; sodium L-ascorbate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water; acetone; toluene;
DOI:10.1039/c5ob00066a