E-2508 free base

Base Information

Chemical Name:E-2508 free base
CAS No.:685885-75-0
Molecular Formula:C29H39N3O4
Molecular Weight:493.646
Hs Code.:
UNII:O90RQ1XQ79
Nikkaji Number:J2.971.745A
Wikidata:Q27285495
Pharos Ligand ID:TP5L4AW7LAZB
ChEMBL ID:CHEMBL2087567

Synonyms:E2508;N-(cyclopropylmethyl)-7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-ethyl-N-((tetrahydro-2H-pyran-4-yl)methyl)pyrazolo(1,5-a)pyridin-3-amine;N-(cyclopropylmethyl)-7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-ethyl-N-((tetrahydro-2H-pyran-4-yl)methyl)pyrazolo(1,5-a)pyridin-3-amine 4-methylbenzenesulfonate

Suppliers and Price of E-2508 free base

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of E-2508 free base

Chemical Property:

PSA：57.46000
Density:1.21±0.1 g/cm3(Predicted)
LogP:5.37030
XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:493.29405673
Heavy Atom Count:36
Complexity:659

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=NN2C(=C1N(CC3CC3)CC4CCOCC4)C=CC=C2C5=C(C=C(C=C5OC)COC)OC

Technology Process of E-2508 free base

There total 28 articles about E-2508 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 685885-79-4
[4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

: 77-78-1
dimethyl sulfate

: 685885-75-0
N-(cyclopropylmethyl)-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;

Reference yield: 84.0%

: N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylamine

: 132291-95-3
4-(methanesulfonyloxymethyl)tetrahydropyran

: 685885-75-0
N-(cyclopropylmethyl)-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine

Guidance literature:: With sodium carbonate; sodium iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1.5h;

Reference yield: 54.0%

: 685886-67-3
[2,6-dimethoxy-4-(methoxymethyl)phenyl]boronic acid

: 685886-48-0
7-bromo-N-(cyclopropylmethyl)-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine

: 685885-75-0
N-(cyclopropylmethyl)-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; In 1,2-dimethoxyethane; water; at 90 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm300259r