[4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

Base Information

Chemical Name:[4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol
CAS No.:685885-79-4
Molecular Formula:C₂₈H₃₇N₃O₄
Molecular Weight:479.619
Hs Code.:

Synonyms:[4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

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Chemical Property of [4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

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Technology Process of [4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

There total 10 articles about [4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 332394-37-3
[4-(hydroxymethyl)-2,6-dimethoxyphenyl]boronic acid

: 685886-48-0
7-bromo-N-(cyclopropylmethyl)-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine

: 685885-79-4
[4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; In 1,2-dimethoxyethane; water; at 90 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm300259r

Reference yield: 89.9%

: 332394-37-3
[4-(hydroxymethyl)-2,6-dimethoxyphenyl]boronic acid

: N-cyclopropylmethyl-N-(2-ethyl-7-iodopyrazolo[1,5-a]pyridine-3-yl)-N-(tetrahydro-2H-pyran-4-ylmethyl)amine hydrochloride

: 685885-79-4
[4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

Guidance literature:: With potassium carbonate; palladium diacetate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 90 - 94 ℃; for 11.15h; Product distribution / selectivity; Inert atmosphere;

Reference yield: 82.8%

: 1144100-29-7
N-(cyclopropylmethyl)-7-{2,6-dimethoxy-4-[(tetrahydro-2H-pyran-2-yloxy)methyl]phenyl}-2-ethyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridin-3-amine

: 685885-79-4
[4-(3-{(cyclopropylmethyl)[(tetrahydro-2H-pyran-4-yl)-methyl]amino}-2-ethylpyrazolo[1,5-a]pyridin-7-yl)-3,5-dimethoxyphenyl]methanol

Guidance literature:: N-(cyclopropylmethyl)-7-{2,6-dimethoxy-4-[(tetrahydro-2H-pyran-2-yloxy)methyl]phenyl}-2-ethyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridin-3-amine; With hydrogenchloride; In water; toluene; at 20 ℃; for 3h;

With sodium hydroxide; In water; ethyl acetate; pH=13;

With sodium hydroxide; Product distribution / selectivity;