2-Piperidineacetic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2R)-

Base Information

• Chemical Name: 2-Piperidineacetic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2R)-
• CAS No.: 686343-39-5
• Molecular Formula: C16H23NO2
• Molecular Weight: 261.364
• Mol file: 686343-39-5.mol

Synonyms:

Chemical Property of 2-Piperidineacetic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Piperidineacetic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2R)-

There total 7 articles about 2-Piperidineacetic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(S)-1-phenyl-ethylamine (2627-86-3) + 7-oxo-hept-2-ynoic acid methyl ester (135284-85-4) → methyl [1-(1-(S)-phenylethyl)-piperidin-2-(R)-yl]acetate (686343-39-5) + (1R,2S)-2-((S)-1-Phenyl-ethylamino)-cyclohexanecarboxylic acid methyl ester

Guidance literature:

(S)-1-phenyl-ethylamine; 7-oxo-hept-2-ynoic acid methyl ester; With magnesium sulfate; In dichloromethane; at 20 ℃; for 24h;

With hydrogen; platinum(IV) oxide; In methanol; at 20 ℃; for 8h;

DOI:10.1021/jo049961c

Reference yield: 54.0%

(S)-1-phenyl-ethylamine (2627-86-3) + methyl 7-mesylhept-2-enoate (66120-16-9) → methyl 2-{(S)-1-[(S)-phenylethyl]piperidin-2-yl}acetate (882872-73-3) + methyl [1-(1-(S)-phenylethyl)-piperidin-2-(R)-yl]acetate (686343-39-5)

Guidance literature:

With triethylamine; at 50 ℃; for 36h;

DOI:10.1055/s-2006-926419

Reference yield:

1-[(1S)-phenylethyl]-2-[(methoxycarbonyl)methyliden]piperidine (882872-58-4) → methyl 2-{(S)-1-[(S)-phenylethyl]piperidin-2-yl}acetate (882872-73-3) + methyl [1-(1-(S)-phenylethyl)-piperidin-2-(R)-yl]acetate (686343-39-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dimethoxyethane; at 20 ℃; for 7h;

DOI:10.1016/j.tet.2005.12.014

upstream raw materials:

(S)-1-phenyl-ethylamine

7-oxo-hept-2-ynoic acid methyl ester

1-[(1S)-phenylethyl]-2-[(methoxycarbonyl)methyliden]piperidine

methyl 7-mesylhept-2-enoate

Downstream raw materials:

methyl (R)-(2-piperidino)acetate