1H-Pyrazole, 4,5-dihydro-1-acetyl-3-(2-(3-chloro-2-(1H-indol-3-yl)-4-oxo-1-azetidinyl)phenyl)-5-(3-chlorophenyl)-

Base Information

Chemical Name:1H-Pyrazole, 4,5-dihydro-1-acetyl-3-(2-(3-chloro-2-(1H-indol-3-yl)-4-oxo-1-azetidinyl)phenyl)-5-(3-chlorophenyl)-
CAS No.:93415-46-4
Molecular Formula:C₂₈H₂₂Cl₂N₄O₂
Molecular Weight:517.414
Hs Code.:
DSSTox Substance ID:DTXSID70918446

Synonyms:BRN 4617434;1H-Pyrazole, 4,5-dihydro-1-acetyl-3-(2-(3-chloro-2-(1H-indol-3-yl)-4-oxo-1-azetidinyl)phenyl)-5-(3-chlorophenyl)-;93415-46-4;DTXSID70918446;1-{2-[1-Acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}-3-chloro-4-(1H-indol-3-yl)azetidin-2-one

Suppliers and Price of 1H-Pyrazole, 4,5-dihydro-1-acetyl-3-(2-(3-chloro-2-(1H-indol-3-yl)-4-oxo-1-azetidinyl)phenyl)-5-(3-chlorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole, 4,5-dihydro-1-acetyl-3-(2-(3-chloro-2-(1H-indol-3-yl)-4-oxo-1-azetidinyl)phenyl)-5-(3-chlorophenyl)-

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:516.1119813
Heavy Atom Count:36
Complexity:899

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1C(CC(=N1)C2=CC=CC=C2N3C(C(C3=O)Cl)C4=CNC5=CC=CC=C54)C6=CC(=CC=C6)Cl

Technology Process of 1H-Pyrazole, 4,5-dihydro-1-acetyl-3-(2-(3-chloro-2-(1H-indol-3-yl)-4-oxo-1-azetidinyl)phenyl)-5-(3-chlorophenyl)-

There total 5 articles about 1H-Pyrazole, 4,5-dihydro-1-acetyl-3-(2-(3-chloro-2-(1H-indol-3-yl)-4-oxo-1-azetidinyl)phenyl)-5-(3-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 93415-42-0
1-acetyl-5-(3-chlorophenyl)-3--2-pyrazoline

: 79-04-9
chloroacetyl chloride

: 93415-46-4
1-{2-[1-Acetyl-5-(3-chloro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-phenyl}-3-chloro-4-(1H-indol-3-yl)-azetidin-2-one

Guidance literature:: With triethylamine; In benzene; Ambient temperature;

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 93415-46-4
1-{2-[1-Acetyl-5-(3-chloro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-phenyl}-3-chloro-4-(1H-indol-3-yl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / methanol / 18 h / Heating

2: 70 percent / piperidine / ethanol / Heating

3: 65 percent / H₂N-NH₂*H₂O / ethanol / 8 h / Heating

4: 40 percent / Et₃N / benzene / Ambient temperature

With piperidine; hydrazine hydrate; triethylamine; In methanol; ethanol; benzene;

Reference yield:

: 551-93-9
2-aminoacetophenone

: 93415-46-4
1-{2-[1-Acetyl-5-(3-chloro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-phenyl}-3-chloro-4-(1H-indol-3-yl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / methanol / 18 h / Heating

2: 70 percent / piperidine / ethanol / Heating

3: 65 percent / H₂N-NH₂*H₂O / ethanol / 8 h / Heating

4: 40 percent / Et₃N / benzene / Ambient temperature

With piperidine; hydrazine hydrate; triethylamine; In methanol; ethanol; benzene;