2,3-Dihydroxypropanenitrile

Base Information

• Chemical Name: 2,3-Dihydroxypropanenitrile
• CAS No.: 69470-43-5
• Molecular Formula: C3H5NO2
• Molecular Weight: 87.0782
• DSSTox Substance ID: DTXSID90524442
• Nikkaji Number: J1.947.167E
• Mol file: 69470-43-5.mol

Synonyms:2,3-Dihydroxypropanenitrile;glyceronitrile;69470-43-5;DTXSID90524442

Chemical Property of 2,3-Dihydroxypropanenitrile

Chemical Property:

• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 87.032028402
• Heavy Atom Count: 6
• Complexity: 72.1

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C#N)O)O

Technology Process of 2,3-Dihydroxypropanenitrile

There total 4 articles about 2,3-Dihydroxypropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogen cyanide (74-90-8) + formaldehyde hydrogen sulfite (7494-19-1) → rac-2,3-Dihydroxypropannitril (69470-43-5) + 2,3,4-trihydroxybutanenitrile (876510-83-7) + Glycolaldehyde (141-46-8)

Guidance literature:

With sodium sulfite; potassium ferrocyanide; In aq. phosphate buffer; water; water-d2; for 3h;

DOI:10.1039/c8cc01499j

Reference yield:

[13C]-formaldehyde (3228-27-1,89277-65-6) + potassium [13C]cyanide → rac-2,3-Dihydroxypropannitril (69470-43-5) + 2,3,4-trihydroxybutanenitrile (876510-83-7)

Guidance literature:

With sodium sulfite; potassium ferrocyanide; In aq. phosphate buffer; water; water-d2;

DOI:10.1039/c8cc01499j

Reference yield:

Glycolaldehyde (141-46-8) → ethane-1,1-diol (4433-56-1) + rac-2,3-Dihydroxypropannitril (69470-43-5) + glycolaldehyde hydrate (40460-44-4) + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

With sodium dihydrogenphosphate dihydrate; sodium monohydrogensulphide hydrate; water; potassium thioacyanate; copper(l) cyanide; In water-d2; for 2h; pH=6.8 - 7; Reagent/catalyst; Time; Irradiation; Inert atmosphere;

DOI:10.1002/anie.201300321

upstream raw materials:

Glycolaldehyde

glycolonitrile

hydrogen cyanide

formaldehyde hydrogen sulfite

Downstream raw materials:

3-picryloxy-2-hydroxypropionitrile