4-Bromo-3-fluorobenzoyl chloride

Base Information

• Chemical Name: 4-Bromo-3-fluorobenzoyl chloride
• CAS No.: 695188-21-7
• Molecular Formula: C7H3BrClFO
• Molecular Weight: 237.456
• Hs Code.: 2916399090
• Mol file: 695188-21-7.mol

Synonyms:4-bromo-3-fluoro-benzoic acid chloride;4-bromo-3-fluoro-benzoyl chloride;PC8605;

Chemical Property of 4-Bromo-3-fluorobenzoyl chloride

Chemical Property:

• Vapor Pressure: 0.0276mmHg at 25°C
• Boiling Point: 246.1oC at 760 mmHg
• Flash Point: 102.6oC
• PSA: 17.07000
• Density: 1.742g/cm3
• LogP: 2.96720

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-3-fluorobenzoylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-3-fluorobenzoyl chloride

There total 3 articles about 4-Bromo-3-fluorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-3-fluorobenzoic acid (153556-42-4) → 4-bromo-3-fluorobenzoyl chloride (695188-21-7)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

4-bromo-3-fluoroiodobenzene (136434-77-0) → 4-bromo-3-fluorobenzoyl chloride (695188-21-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 125 ℃; for 12h;

DOI:10.1038/s41557-018-0078-8

Reference yield:

→ 4-bromo-3-fluorobenzoyl chloride (695188-21-7)

Guidance literature:

upstream raw materials:

4-bromo-3-fluorobenzoic acid

4-bromo-3-fluoroiodobenzene

Downstream raw materials:

4-bromo-3-fluoro-N-(6-methylpyridin-2-yl)benzamide

4-bromo-3-fluoro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide