N-[2-(2,6-Dichlorophenylamino)phenylacetyl]glycine

Base Information

• Chemical Name: N-[2-(2,6-Dichlorophenylamino)phenylacetyl]glycine
• CAS No.: 69630-31-5
• Molecular Formula: C16H14Cl2N2O3
• Molecular Weight: 353.205
• DSSTox Substance ID: DTXSID501197875
• Nikkaji Number: J839.706F
• Mol file: 69630-31-5.mol

Synonyms:Oprea1_733738;SCHEMBL11195479;DTXSID501197875;N-[2-(2,6-Dichlorophenylamino)phenylacetyl]glycine;Glycine, N-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]-;69630-31-5

Chemical Property of N-[2-(2,6-Dichlorophenylamino)phenylacetyl]glycine

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 352.0381477
• Heavy Atom Count: 23
• Complexity: 412

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CC(=O)NCC(=O)O)NC2=C(C=CC=C2Cl)Cl

Technology Process of N-[2-(2,6-Dichlorophenylamino)phenylacetyl]glycine

There total 6 articles about N-[2-(2,6-Dichlorophenylamino)phenylacetyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acetic acid N-oxysuccinimide ester (104425-36-7) + glycine (56-40-6,18875-39-3,25718-94-9) → acetylglycine (69630-31-5)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; for 24h;

Reference yield: 55.0%

{2-[2-(2,6-Dichloro-phenylamino)-phenyl]-acetylamino}-acetic acid methyl ester (192377-01-8) → acetylglycine (69630-31-5)

Guidance literature:

With potassium hydroxide; In ethanol; 1.) reflux, 2 min; 50 deg C, 3 h;

Reference yield:

[2-(2,6-dichloroanilino)phenyl]acetic acid (15307-86-5) + glycine (56-40-6,18875-39-3,25718-94-9) → acetylglycine (69630-31-5)

Guidance literature:

[2-(2,6-dichloroanilino)phenyl]acetic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

glycine; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 6h;

upstream raw materials:

acetic acid N-oxysuccinimide ester

glycine

{2-[2-(2,6-Dichloro-phenylamino)-phenyl]-acetylamino}-acetic acid methyl ester

[2-(2,6-dichloroanilino)phenyl]acetic acid

Downstream raw materials:

(2-{2-[2-(2,6-dichloro-phenylamino)-phenyl]-acetylamino}-acetylamino)-acetic acid methyl ester